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How a brain hormone controls insect metamorphosis

Date:
December 4, 2009
Source:
University of Minnesota
Summary:
Researchers have discovered how PTTH, a hormone produced by the brain, controls the metamorphosis of juvenile insects into adults.
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Various views of a monarch butterfly emerging from its chrysalis. Researchers have discovered how PTTH, a hormone produced by the brain, controls the metamorphosis of juvenile insects into adults.
Credit: iStockphoto/Cathy Keifer

A team of University of Minnesota researchers have discovered how PTTH, a hormone produced by the brain, controls the metamorphosis of juvenile insects into adults.

The finding, published in the Dec. 4 issue of Science, will help scientists understand how insect body size is programmed in response to developmental and environmental cues and offers the opportunity to develop a new generation of more environmentally safe ways to control agricultural pests as well as insects that carry human pathogens.

Scientists have known for 100 years that a brain-derived neuropeptide known as PTTH controls metamorphosis and although its specific sequence was identified 20 years ago, the way it signaled endocrine tissue has remained elusive until now.

"Understanding the signaling pathway that controls metamorphosis has been a long-term goal for many insect physiologists," says lead author Michael O'Connor, professor of genetics, cell biology and development at the University of Minnesota's College of Biological Sciences, where he holds the Ordway Chair in Developmental Biology.

Although humans don't undergo metamorphosis, passage from childhood through puberty and development of adult sexual characteristics is also regulated by a brain-derived neuropeptide that is controlled by genetics, environment and nutrition. Understanding how this process works in insects sheds light on human development.

"In its overall design, insect metamorphosis is very much like passage through puberty," O'Connor says. "From a biological point of view, both puberty and metamorphosis accomplish the same goal -- to provide reproductive capacity for the species at the appropriate developmental time." The brain hormone becomes active when insects have reached a threshold body weight, which is also a trigger for human puberty.

Fruit flies and silk moths were used for the study; however, all insects that undergo complete metamorphosis appear to use this signaling system, O'Connor says. His next step is to learn how environmental and nutritional cues regulate the production of PTTH (prothoracicotropic hormone).

Co-authors for the Science paper are U of M postdoctoral researchers Kim Rewitz and Naoki Yamanaka and Lawrence Gilbert, who is an emeritus biology professor at the University of North Carolina.


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The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


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University of Minnesota. "How a brain hormone controls insect metamorphosis." ScienceDaily. ScienceDaily, 4 December 2009. <www.sciencedaily.com/releases/2009/12/091203141859.htm>.
University of Minnesota. (2009, December 4). How a brain hormone controls insect metamorphosis. ScienceDaily. Retrieved May 25, 2015 from www.sciencedaily.com/releases/2009/12/091203141859.htm
University of Minnesota. "How a brain hormone controls insect metamorphosis." ScienceDaily. www.sciencedaily.com/releases/2009/12/091203141859.htm (accessed May 25, 2015).

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