Featured Research

from universities, journals, and other organizations

Why cancer cells just won't die: Researcher identifies protein which regulates cell suicide

Date:
December 10, 2009
Source:
University of Western Ontario
Summary:
When cells experience DNA damage, they'll try to repair it. But if that fails, the damaged cells are supposed to self-destruct, a process called apoptosis. A cancer researcher has identified a protein that regulates apoptosis, a new discovery which has implications for both the diagnosis and treatment of cancer.

When cells experience DNA damage, they'll try to repair it. But if that fails, the damaged cells are supposed to self-destruct, a process called apoptosis. A cancer researcher at Robarts Research Institute at The University of Western Ontario has identified a protein that regulates apoptosis, a new discovery which has implications for both the diagnosis and treatment of cancer.

Related Articles


Caroline Schild-Poulter's findings are now published online in the journal Molecular Cancer Research.

"The protein we've identified, RanBPM, is directly involved in activating apoptosis," explains Schild-Poulter who is also an assistant professor in the Department of Biochemistry at Western's Schulich School of Medicine & Dentistry. "One of the hallmarks of cancer is that the cells don't initiate apoptosis despite having defects in their genetic material. In other words the damaged cells do not commit suicide, and this develops into cancer. Failure to activate apoptosis also makes it difficult to cure cancer. You cannot kill these cells by causing DNA damage to them using chemotherapy or radiation, because these cells resist dying."

While more research is needed to fully understand how this protein functions, Schild-Poulter believes RanBPM could be targeted to re-activate apoptosis, killing cancer cells. The protein may also be a marker used to predict whether a tumour will go on to become malignant.

Schild-Poulter holds the position of "Fuller Scientist" at Robarts Research. Her research is funded through a donation from Marilynne Fuller, whose husband Robert died of cancer in 2002.


Story Source:

The above story is based on materials provided by University of Western Ontario. Note: Materials may be edited for content and length.


Cite This Page:

University of Western Ontario. "Why cancer cells just won't die: Researcher identifies protein which regulates cell suicide." ScienceDaily. ScienceDaily, 10 December 2009. <www.sciencedaily.com/releases/2009/12/091209114158.htm>.
University of Western Ontario. (2009, December 10). Why cancer cells just won't die: Researcher identifies protein which regulates cell suicide. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2009/12/091209114158.htm
University of Western Ontario. "Why cancer cells just won't die: Researcher identifies protein which regulates cell suicide." ScienceDaily. www.sciencedaily.com/releases/2009/12/091209114158.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins