Featured Research

from universities, journals, and other organizations

Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae

Date:
December 31, 2009
Source:
Columbia University's Mailman School of Public Health
Summary:
The presence of the Streptococcus pneumoniae in samples that can be easily obtained in clinics and emergency rooms may predict risk of severe disease in H1N1 pandemic influenza. Reports that H1N1 pandemic influenza in Argentina was associated with higher morbidity and mortality than in other countries led investigators in the Center for Infection and Immunity at the Mailman School of Public Health to look for viral mutations indicative of increased virulence and for co-infections that could contribute to disease.

Streptococcus pneumoniae bacterial colonies.
Credit: CDC/Dr. Richard Facklam

The presence of the Streptococcus pneumoniae in samples that can be easily obtained in clinics and emergency rooms may predict risk of severe disease in H1N1 pandemic influenza.

Reports that H1N1 pandemic influenza in Argentina was associated with higher morbidity and mortality than in other countries led investigators in the Center for Infection and Immunity (CII) at the Mailman School of Public Health of Columbia University, their colleagues at Argentina's National Institute of Infectious Diseases (INEI), and Roche 454 Life Sciences to look for viral mutations indicative of increased virulence and for co-infections that could contribute to disease.

Complete genome sequencing of nasopharyngeal samples representing severe or mild disease revealed no evidence of evolution toward a more virulent phenotype or development of antiviral resistance. However, MassTag PCR, a method for sensitive, simultaneous surveillance and differential diagnosis of infectious diseases, found a strong correlation between the presence of Streptococcus pneumoniae and increased risk for severe disease. The findings, which suggest a new strategy for identifying and treating these patients, are currently online in the publication Plos One.

The scientists examined nasopharyngeal samples representing 199 cases of H1N1 pandemic (H1N1pdm) influenza virus infections from Argentina. The sample set included 39 cases classified as severe and 160 cases categorized as mild.

"We used a combination of 454 pyrosequencing and classical Sanger sequencing methods to test for viral evolution toward increased virulence. Comparison of viral sequences from Argentina with those obtained from other parts of the world provided no clues to the increase in severity of disease," said Gustavo Palacios, PhD, assistant professor of epidemiology at CII, and a lead and corresponding author. "However, MassTag PCR allowed us to find a new risk factor, independent of obesity, asthma, diabetes or chronic illness. S. pneumoniae was present in the majority of severe cases."

Specimens were tested for the presence of 33 viral and bacterial respiratory pathogens. "The presence of Streptococcus pneumoniae in individuals between the age of 6 and 55, those most affected by the current pandemic, was associated with a 125-fold increased risk of severe disease," said Mady Hornig, MD, associate professor of epidemiology and a co-first author of the paper.

"Whereas the association of S. pneumoniae with morbidity and mortality had been established in current and previous influenza pandemics, this study is the first to demonstrate that the diagnosis of S. pneumoniae, when it is still actionable, might have an impact on clinical management."

"Three practical implications emerge from our study," said CII Director W. Ian Lipkin, MD, John Snow Professor of Epidemiology, and professor of Neurology and Pathology at Columbia University. "First, S. pneumoniae is important in the pathogenesis and prognosis of H1N1pdm-associated disease. Whether this effect is associated with all S. pneumoniae or only with specific serotypes remains to be determined. Second, easily accessible samples such as nasopharyngeal swab samples may be used as an index to risk of severe disease. Third, multiplex diagnostic methods like MassTag PCR can enable rapid detection of a broad spectrum of viral and bacterial agents and inform clinical care."


Story Source:

The above story is based on materials provided by Columbia University's Mailman School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Palacios et al. Streptococcus pneumoniae Coinfection Is Correlated with the Severity of H1N1 Pandemic Influenza. PLoS ONE, 2009; 4 (12): e8540 DOI: 10.1371/journal.pone.0008540

Cite This Page:

Columbia University's Mailman School of Public Health. "Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae." ScienceDaily. ScienceDaily, 31 December 2009. <www.sciencedaily.com/releases/2009/12/091230201419.htm>.
Columbia University's Mailman School of Public Health. (2009, December 31). Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/12/091230201419.htm
Columbia University's Mailman School of Public Health. "Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae." ScienceDaily. www.sciencedaily.com/releases/2009/12/091230201419.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins