Featured Research

from universities, journals, and other organizations

Zebrafish journal publishes cancer biology special issue

Date:
January 7, 2010
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
The zebrafish, a translucent fish often used as a model of human development and disease, offers unique advantages for studying the cause, growth, and spread of tumors using strategies and methods presented in the current cancer biology special issue of Zebrafish, a peer-reviewed journal published by Mary Ann Liebert, Inc.

The zebrafish, a translucent fish often used as a model of human development and disease, offers unique advantages for studying the cause, growth, and spread of tumors using strategies and methods presented in the current "Cancer Biology" special issue of Zebrafish, a peer-reviewed journal published by Mary Ann Liebert, Inc.

The entire issue is available free online at www.liebertpub.com/zeb

Guest Editors Steven D. Leach, MD, the Paul K. Neumann Professor in Pancreatic Cancer and Professor of Surgery, Oncology and Cell Biology at Johns Hopkins University (Baltimore, MD) and A. Thomas Look, MD, Professor, Department of Pediatrics, Harvard Medical School, and Vice-Chair for Research Pediatric Oncology, Dana Farber Cancer Institute (Boston, MA), have compiled a comprehensive collection of papers that describe current approaches for modeling human cancer in zebrafish, studying tissue remodeling in zebrafish embryos, and understanding the genes, genetic control elements, and repair pathways involved in the development and metastasis of tumors.

A particular advantage of using zebrafish to study cancer biology is the ability to transplant human tumors into the fish using well-established methods. Authors Leonard Zon, PhD, and Alison Taylor, PhD, from Harvard Medical School and Children's Hospital Boston present the concepts and techniques relevant to zebrafish transplantation assays. They describe how tumor transplantation has been used to study leukemia, rhabdomyosarcoma, and melanoma in the paper "Zebrafish Tumor Assays: The State of Transplantation."

The molecular basis for cancers affecting human germ cells is poorly understood, impeding efforts to identify more effective and targeted treatments. In the paper entitled "Identification of a Heritable Model of Testicular Germ Cell Tumor in the Zebrafish," authors Joanie Neumann, Jennifer Dhepard Dovey, Garvin Chandler, Liliana Carbajal, and James Amatruda, describe the development of a zebrafish model that carries a genetic mutation making the fish highly susceptible to the development of testicular tumors. This model system can be used to test new approaches to therapy for testicular cancer.

Jun Chen and Jinrong Peng, from Zhejian University (China), describe the use of transgenic zebrafish to understand the roles that different naturally occurring forms of the tumor suppressor gene p53 play in regulating cell cycle, metabolism, organ development, and cell aging and death. Their paper "p53 Isoform Δ113p53 in Zebrafish" discusses the potential use of this particular p53 isoform for characterizing factors in the p53 pathway and screening for novel cancer therapies.

Noting the "relative ease and low costs of transgenesis" -- putting human genes into zebrafish -- and the unique benefits of working with zebrafish, especially related to imaging, genetics, and transplantation, Dr. Leach predicts that, "Future zebrafish cancer research exploiting these fundamental advantages will be especially likely to generate novel insights not achievable using other model systems," in his Introduction to the issue entitled, "Pisces and Cancer: The Stars Align."


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "Zebrafish journal publishes cancer biology special issue." ScienceDaily. ScienceDaily, 7 January 2010. <www.sciencedaily.com/releases/2010/01/100107183045.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2010, January 7). Zebrafish journal publishes cancer biology special issue. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/01/100107183045.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "Zebrafish journal publishes cancer biology special issue." ScienceDaily. www.sciencedaily.com/releases/2010/01/100107183045.htm (accessed September 30, 2014).

Share This



More Plants & Animals News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Dolphins Might Use Earth's Magnetic Field As A GPS

Dolphins Might Use Earth's Magnetic Field As A GPS

Newsy (Sep. 30, 2014) A study released Monday suggests dolphins might be able to sense the Earth's magnetic field and possibly use it as a means of navigation. Video provided by Newsy
Powered by NewsLook.com
How To Battle Stink Bug Season

How To Battle Stink Bug Season

Newsy (Sep. 30, 2014) Homeowners in 33 states grapple with stink bugs moving indoors at this time of year. Here are a few tips to avoid stink bug infestations. Video provided by Newsy
Powered by NewsLook.com
California University Designs Sustainable Winery

California University Designs Sustainable Winery

Reuters - US Online Video (Sep. 27, 2014) Amid California's worst drought in decades, scientists at UC Davis design a sustainable winery that includes a water recycling system. Vanessa Johnston reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins