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Treatment for chronic hepatitis C: A phase II study

Date:
January 15, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Italy conducted a phase II study evaluating the molecular and clinical effect of ketoprofen plus pegylated interferon with or without ribavirin in patients with genotype 1 chronic hepatitis C. Their results on hepatitis C virus kinetics and interferon signaling, together with the efficacy and safety data, offer the rationale to further explore this three-drug combination in chronic hepatitis C, especially in difficult to treat patients.
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FULL STORY

A research team from Italy conducted a phase II study evaluating the molecular and clinical effect of ketoprofen plus pegylated interferon with or without ribavirin in patients with genotype 1 chronic hepatitis C. Their results on hepatitis C virus kinetics and interferon signaling, together with the efficacy and safety data, offer the rationale to further explore this three-drug combination in chronic hepatitis C, especially in difficult to treat patients.

The current standard treatment for chronic hepatitis C with pegylated-interferon (PEG-IFN) and ribavirin is effective in approximately 50%-60% of patients, so that a substantial proportion of patients remain unresponsive. A rational approach to develop alternative therapeutic strategies for patients with chronic hepatitis C virus (HCV) infection demands a detailed knowledge of how the different drugs affect viral kinetics and IFN intracellular signaling. Non-steroidal antiinflammatory drugs (NSAIDs) have been demonstrated to amplify the IFN signaling pathways and to enhance the anti-viral effect of IFN.

Based on previous data, a research team from Italy evaluated the safety of adding ketoprofen to pegylated-interferon (PEG-IFN) with or without ribavirin and the effect on viral kinetics, signal transducer and activator of transcription 1 (STAT1) activity and expression of 2'-5'-oligoadenylate synthetase (2'-5'OAS) in genotype 1 chronic hepatitis C in a phase Ⅱ study. Their study will be published on December 21, 2009 in the World Journal of Gastroenterology.

Their research found that the addition of ketoprofen to the conventional combination therapy is associated with better viral kinetics and early activation of the IFNa signaling pathway, thus improving virological response rates. The authors postulated that a larger trial should be done with this three-drug combination, compared to the standard of care.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gramenzi A, Cursaro C, Margotti M, Balsano C, Spaziani A, Anticoli S, Loggi E, Salerno M, Galli S, Furlini G, Bernardi M, Andreone P. Ketoprofen, peginterferon 2a and ribavirin for genotype 1 chronic hepatitis C: A phase II study. World Journal of Gastroenterology, 2009; 15 (47): 5946 DOI: 10.3748/wjg.15.5946

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World Journal of Gastroenterology. "Treatment for chronic hepatitis C: A phase II study." ScienceDaily. ScienceDaily, 15 January 2010. <www.sciencedaily.com/releases/2010/01/100115093845.htm>.
World Journal of Gastroenterology. (2010, January 15). Treatment for chronic hepatitis C: A phase II study. ScienceDaily. Retrieved May 23, 2015 from www.sciencedaily.com/releases/2010/01/100115093845.htm
World Journal of Gastroenterology. "Treatment for chronic hepatitis C: A phase II study." ScienceDaily. www.sciencedaily.com/releases/2010/01/100115093845.htm (accessed May 23, 2015).

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