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Cells critical to childhood leukemia discovered

Date:
January 25, 2010
Source:
University of Melbourne
Summary:
Scientists have discovered the cells that cause a common type of childhood leukemia -- T cell Acute Lymphoblastic Leukemia. Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.
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Scientists at The Royal Melbourne Hospital and the University of Melbourne in Australia have discovered the cells that cause a common type of childhood leukaemia -- T cell Acute Lymphoblastic Leukaemia (T-ALL). Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.

The team, led by Dr Matthew McCormack and Dr David Curtis of the Rotary Bone Marrow Research Laboratories and the University's Department of Medicine at The Royal Melbourne Hospital, made the discovery whilst studying mice prone to developing this leukaemia.

The results have been published online January 21 by the journal Science.

The team found that with irradiation treatment in animal models, over 99 per cent of cells in the thymus were killed, but these stem cell-like cells persisted and rapidly recovered. This suggests that these cells may survive therapy and be responsible for relapsed disease following treatment.

Currently, children with T-ALL are given extended therapy over two to three years in an attempt to stop a relapse. More targeted therapy on the thymus cells could reduce the length and toxicity of treatment and prevent relapse.

Dr McCormack, a leading international expert on childhood leukaemia, said: "The cellular origins of this leukaemia are not well understood. Our discovery that these cells are similar to normal stem cells explains why they are capable of surviving for long periods. It also explains why they are remarkably resistant to treatment."

Approximately 50 new cases of T-ALL are diagnosed every year in Australia, two thirds of these in children or adolescents. Adults also contract T-ALL, and the majority succumb to resistant or relapsed disease.

Dr Curtis, a Clinical Haematologist and head of the Leukaemia Research Program at The Royal Melbourne Hospital, said: "The identification of these cells provides an important target for the development and testing of new treatments for patients with T cell Acute Lymphoblastic Leukaemia."

The team will now focus on novel treatments capable of killing these cells, which may lead to clinical trials within the next five years.

The research also involved Walter & Eliza Hall Institute of Medical Research and Leeds Institute of Molecular Medicine, UK.

The research was supported by the National Health and Medical Research Council of Australia, Cancer Council Victoria, Leukaemia Foundation of Australia and the Fight Cancer Foundation (BMDI).


Story Source:

The above post is reprinted from materials provided by University of Melbourne. Note: Materials may be edited for content and length.


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University of Melbourne. "Cells critical to childhood leukemia discovered." ScienceDaily. ScienceDaily, 25 January 2010. <www.sciencedaily.com/releases/2010/01/100121141059.htm>.
University of Melbourne. (2010, January 25). Cells critical to childhood leukemia discovered. ScienceDaily. Retrieved July 29, 2015 from www.sciencedaily.com/releases/2010/01/100121141059.htm
University of Melbourne. "Cells critical to childhood leukemia discovered." ScienceDaily. www.sciencedaily.com/releases/2010/01/100121141059.htm (accessed July 29, 2015).

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