Featured Research

from universities, journals, and other organizations

Changes in body fluid odors indicate presence of lung cancer tumors

Date:
January 27, 2010
Source:
Monell Chemical Senses Center
Summary:
New animal research demonstrates that body fluid odors can be used to identify animals with lung cancer tumors. The findings set the stage for studies to identify potential diagnostic biomarkers in the urine of human lung cancer patients.

New animal research from scientists at the Monell Center and collaborators demonstrates that body fluid odors can be used to identify animals with lung cancer tumors. The findings set the stage for studies to identify potential diagnostic biomarkers in the urine of human lung cancer patients.

Lung cancer is the leading cause of cancer-related deaths worldwide, responsible for 1.3 million deaths annually. Effective techniques for early diagnosis are urgently needed, as the disease often has no early signs or symptoms.

"Cancer tumors result in a change in body-related odors that can be detected both by trained animal sensors and by sophisticated chemical techniques," said Monell biologist Gary K. Beauchamp, Ph.D., a senior author on the study. "These findings indicate that odor sensing has the potential to improve early diagnostic and prognostic approaches to lung cancer treatment."

Anecdotal reports have suggested that odor changes might be used to identify individuals affected with cancer, but experimental work in this area has not been conclusive. The current study, reported in the online journal PLoS One, used a rigorously controlled animal model to eliminate many confounding factors frequently found in human patient studies.

In behavioral studies, sensor mice were first trained to recognize the scent of urine from animals bearing lung cancer tumors. The trained sensor mice were then able to use urine odor to distinguish tumor-bearing from healthy animals.

Chemical analyses of urine compounds revealed that the amounts of several chemical compounds differed dramatically between tumor-bearing and healthy mice. Surprisingly, the levels of many of these compounds were decreased in tumor-bearing mice rather than increased, which is what often is expected.

In subsequent experiments, the researchers were able to identify tumor-bearing from control mice simply by measuring the amounts of these biomarker chemicals in mouse urine and then constructing chemical profiles. This chemical classification was sensitive enough to accurately identify 47 out of 50 mice as tumor-bearing or healthy.

The findings indicate that lung cancers produce changes in odorous compounds secreted in urine and that these changes can be detected and used as a diagnostic tool.

"Finding new ways to screen for early lung cancers in patients at risk, such as smokers, is one of the best ways we have to reduce the high death rate from this disease," said Steven M. Albelda, M.D., William Maul Measey Professor of Medicine, University of Pennsylvania School of Medicine, also a senior author on the paper. "Using the same chemical approaches as in this paper, we hope to be able to detect odors in urine of smokers that could be used to identify lung cancer at a very early stage."

Also contributing to the study were first author Koichi Matsumura, Maryanne Opiekun, and Kunio Yamazaki from Monell; Hiroaki Oka from Panasonic Corporation; and Anil Vachani from the University of Pennsylvania School of Medicine. The study was funded by Panasonic Corporation.


Story Source:

The above story is based on materials provided by Monell Chemical Senses Center. Note: Materials may be edited for content and length.


Cite This Page:

Monell Chemical Senses Center. "Changes in body fluid odors indicate presence of lung cancer tumors." ScienceDaily. ScienceDaily, 27 January 2010. <www.sciencedaily.com/releases/2010/01/100126220319.htm>.
Monell Chemical Senses Center. (2010, January 27). Changes in body fluid odors indicate presence of lung cancer tumors. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2010/01/100126220319.htm
Monell Chemical Senses Center. "Changes in body fluid odors indicate presence of lung cancer tumors." ScienceDaily. www.sciencedaily.com/releases/2010/01/100126220319.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins