Featured Research

from universities, journals, and other organizations

Bacteria toxic to wound-treating maggots

Date:
February 5, 2010
Source:
Society for General Microbiology
Summary:
Bacteria that infect chronic wounds can be deadly to maggot "bio-surgeons" used to treat the lesions, show researchers. The findings could lead to more effective treatment of wounds and the development of novel antibiotics.

Bacteria that infect chronic wounds can be deadly to maggot 'biosurgeons' used to treat the lesions, show researchers writing in the journal Microbiology. The findings could lead to more effective treatment of wounds and the development of novel antibiotics.

Related Articles


Scientists from the Copenhagen Wound Healing Centre, Statens Serum Institut and the University of Copenhagen in Denmark showed that maggots applied to simulated wounds heavily infected with the bacterium Pseudomonas aeruginosa, were unable to treat the wound and were left dead after 20 hours.

Chronic wounds, such as leg ulcers, affect 1% of the Western population and are painful and difficult to treat. Use of maggots to disinfect wounds is an ancient practice that regained popularity in the early 1990s. Maggot Debridement Therapy (MDT) is now a standard procedure at wound care centres all over the world, in which sterile larvae from the green bottle fly Lucilia sericata are applied to the wound either directly or contained within a sealed nylon bag. The maggots gently ingest necrotic (dead) tissue and kill ingested bacteria in the gut. In addition, the maggots secrete antimicrobial compounds into the wound, help reduce inflammation and promote wound healing. The actual biological mechanisms responsible for the process are still largely a mystery.

P. aeruginosa is an opportunistic bacterium responsible for many hospital-acquired infections. It is often associated with chronic wounds in which the bacteria clump together to form biofilms. By effectively talking to each other via a well-studied communication system called quorum sensing (QS), bacteria in biofilms are known to be more successful at avoiding destruction by the host immune system as well as antibiotics.

Dr Anders Schou Andersen, who led the research, explained that QS was also the key to P. aeruginosa's toxicity to maggots. "When we blocked the QS signalling pathways in the bacteria, the maggots were much better at surviving and potentially cleansing the wounds. Signalling between bacteria growing in biofilms is known to lead to the production of lethal toxins, without which the bacteria are more vulnerable to eradication."

Dr Andersen believes the research could benefit patients with persistent wounds. "MDT is generally very effective. It has been said that in a few cases MDT had failed, leaving the maggots dead in the lesion. We now think that this was probably due to the presence of P. aeruginosa in the wound," he said. "If we can find the specific bacterial mechanism that kills the maggots, we could target this when developing new treatments. For example, wounds infected with P. aeruginosa could be treated with an agent that interrupts bacterial signalling to ensure the success of maggot therapy and thereby wound healing."


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "Bacteria toxic to wound-treating maggots." ScienceDaily. ScienceDaily, 5 February 2010. <www.sciencedaily.com/releases/2010/02/100204204304.htm>.
Society for General Microbiology. (2010, February 5). Bacteria toxic to wound-treating maggots. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2010/02/100204204304.htm
Society for General Microbiology. "Bacteria toxic to wound-treating maggots." ScienceDaily. www.sciencedaily.com/releases/2010/02/100204204304.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins