Featured Research

from universities, journals, and other organizations

Low levels of natural antibodies behind stroke

Date:
February 13, 2010
Source:
Karolinska Institutet
Summary:
The chances of suffering a stroke are linked to the presence of a certain type of antibody in the immune system, a new study from Sweden shows. The researchers hope to be able to develop a vaccine that can mobilize the body's own defense against arteriosclerosis and stroke.

The chances of suffering a stroke are linked to the presence of a certain type of antibody in the immune system, a new study from Karolinska Institutet shows. The researchers hope to be able to develop a vaccine that can mobilise the body´s own defence against arteriosclerosis and stroke.

The research group, which was led by Professor Johan Frostegård, has previously demonstrated that high levels of a certain type of antibody (anti-PC) in the immune defence are linked to a reduced risk of arteriosclerosis, a common cause of thrombosis and myocardial infarction.

In the present study, published in the journal Stroke, the researchers focused exclusively on stroke -- a blood clot in the brain -- and compared 227 individuals who had suffered stroke over a 13-year period with 445 sex and age-matched controls. After controlling for other risk factors (age, sex, smoking habits, cholesterol levels, diabetes, BMI and blood pressure), they were able to show that low levels (below 30 per cent of average) of PC antibodies correlated with a higher risk of stroke, which in women meant an almost three-fold increase.

The researchers have now advanced the hypothesis that low levels of natural PC antibodies -- which can be a condition of a poor immune system -- contribute to the development of arteriosclerosis and its consequences, which include stroke.

"Were now examining the possibility of developing new immunological treatments for arteriosclerosis and stroke, either in the form of a vaccine to stimulate the immune defence or immunisation through the injection of antibodies," says Professor Frostegård.

Arteriosclerosis is formed by the accumulation of plaque on the walls of blood vessels, which can rupture and form a blood clot. The researchers believe that the PC antibodies react to a substance called phosphorylcholine (PC), which is a component of a class of fat molecules (phospholipids) that go to make up the plaque.

The study was carried out under the EU's CVDIMMUNE consortium, which is led by Johan Frostegård at Karolinska Institutet. The first author, Roland Fiskesund, is a doctoral student in the project, which is based at the Karolinska Institutet's Department of Medicine in Huddinge, Stockholm.



Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Roland Fiskesund, Birgitta Stegmayr, Göran Hallmans, Max Vikström, Lars Weinehall, Ulf de Faire, Johan Frostegård. Low Levels of Antibodies Against Phosphorylcholine Predict Development of Stroke in a Population-Based Study From Northern Sweden. Stroke, 2010; DOI: 10.1161/STROKEAHA.109.558742

Cite This Page:

Karolinska Institutet. "Low levels of natural antibodies behind stroke." ScienceDaily. ScienceDaily, 13 February 2010. <www.sciencedaily.com/releases/2010/02/100212101249.htm>.
Karolinska Institutet. (2010, February 13). Low levels of natural antibodies behind stroke. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/02/100212101249.htm
Karolinska Institutet. "Low levels of natural antibodies behind stroke." ScienceDaily. www.sciencedaily.com/releases/2010/02/100212101249.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) — Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) — Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) — Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) — Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins