Featured Research

from universities, journals, and other organizations

Easing egg allergies with eggs: Oral immunotherapy study shows it works

Date:
March 1, 2010
Source:
Johns Hopkins Medical Institutions
Summary:
Children with egg allergies who consume increasingly higher doses of egg protein -- the very nutrient they react to -- appear to gradually overcome their allergies, tolerating eggs better over time and with milder symptoms, according to new research.

Children with egg allergies who consume increasingly higher doses of egg protein -- the very nutrient they react to -- appear to gradually overcome their allergies, tolerating eggs better over time and with milder symptoms, according to research conducted at Johns Hopkins Children's Center and elsewhere.

The findings from a multi-center trial are to be presented at the annual meeting of the American Academy of Allergy, Asthma & Immunology Feb. 26 through March 2.

Previous research at Hopkins Children's showed that the same approach, known as oral immunotherapy, can be used successfully to treat children with milk allergies. Some of the children in the milk allergy study overcame their condition completely, and many experienced less severe allergic symptoms as a result of the therapy.

Now, researchers are reporting similarly encouraging results in children with egg allergies.

"Just as we saw in our patients with milk allergies before, oral immunotherapy for children with egg allergies works in the same way by slowly retraining the immune system to tolerate the allergens that caused allergic reactions," says study investigator Robert Wood, M.D., director of Allergy & Immunology at Hopkins Children's.

Researchers caution that confirming these early results requires long-term monitoring of the current patients and enrolling more children in the ongoing trials. They also caution that oral immunotherapy should be implemented only by a trained pediatric allergist.

In the 11-month study of 45 children ages 5 to 18, researchers gave 40 patients increasingly higher doses of egg whites during multiple food challenges conducted in a clinic and under a doctor's supervision, while 15 children received placebo, "dummy" food that looks like egg whites but contains no egg protein. All children received higher and higher doses of either placebo or actual egg protein in the course of the 11 months.

At the end of the study, during a final food challenge, more than half of the children who had been consuming eggs (21 out of 40) could tolerate 5 grams of eggs without having an allergic reaction. None of the children who received placebo were able to tolerate eggs during the final food challenge.

When symptoms did occur, investigators say, they were mild to moderate and involved mostly itching and swelling of the mouth and throat.

Children who consumed eggs also had lower blood levels of IgE antibodies -- immune markers that rise during an allergic reaction -- and a significant drop in the levels of egg-specific basophils, a type of while blood cell that multiplies during an allergic reaction.

Food allergies have been steadily rising in the last decade and are becoming harder to outgrow, research shows. An estimated 2 percent to 3 percent of U.S. children have egg allergies.


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Easing egg allergies with eggs: Oral immunotherapy study shows it works." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/02/100228203038.htm>.
Johns Hopkins Medical Institutions. (2010, March 1). Easing egg allergies with eggs: Oral immunotherapy study shows it works. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/02/100228203038.htm
Johns Hopkins Medical Institutions. "Easing egg allergies with eggs: Oral immunotherapy study shows it works." ScienceDaily. www.sciencedaily.com/releases/2010/02/100228203038.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins