Featured Research

from universities, journals, and other organizations

Metabolism: Understanding Resistance To Thyroid Hormones

Date:
March 8, 2010
Source:
Journal of Clinical Investigation
Summary:
One function of thyroid hormones is to control energy availability and expenditure. Some individuals have mutations in their thyroid hormone receptor-beta (THRB) gene and are resistant to the effects of thyroid hormones. This causes their levels of circulating thyroid hormones to become elevated, but the effects of this have not been completely determined. However, researchers now determined that adults and children with THRB mutations have markedly increased resting energy expenditure.

One function of thyroid hormones is to control energy availability and expenditure. Some individuals have mutations in their thyroid hormone receptor-beta (THRB) gene and are resistant to the effects of thyroid hormones. This causes their levels of circulating thyroid hormones to become elevated, but the effects of this have not been completely determined.

Related Articles


However, a team of researchers, led by Kitt Falk Petersen and Krishna Chatterjee, at Yale University School of Medicine, New Haven, and Cambridge University, United Kingdom, has now determined that adults and children with THRB mutations have markedly increased resting energy expenditure.

Further analysis identified a process known as mitochondrial uncoupling in skeletal muscle, due to tissue selective retention of thyroid hormone receptor-alpha sensitivity to elevated thyroid hormone levels, as a predominant mechanism contributing to this effect.

The authors therefore suggest that further studies of individuals resistant to the effects of thyroid hormones will help clarify the relative contribution of different forms of thyroid hormone receptor in different target tissues.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Catherine S. Mitchell, David B. Savage, Sylvie Dufour, Nadia Schoenmakers, Peter Murgatroyd, Douglas Befroy, David Halsall, Samantha Northcott, Philippa Raymond-Barker, Suzanne Curran, Elana Henning, Julia Keogh, Penny Owen, John Lazarus, Douglas L. Rothman, I. Sadaf Farooqi, Gerald I. Shulman, Krishna Chatterjee and Kitt Falk Petersen. Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI38793

Cite This Page:

Journal of Clinical Investigation. "Metabolism: Understanding Resistance To Thyroid Hormones." ScienceDaily. ScienceDaily, 8 March 2010. <www.sciencedaily.com/releases/2010/03/100308220538.htm>.
Journal of Clinical Investigation. (2010, March 8). Metabolism: Understanding Resistance To Thyroid Hormones. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2010/03/100308220538.htm
Journal of Clinical Investigation. "Metabolism: Understanding Resistance To Thyroid Hormones." ScienceDaily. www.sciencedaily.com/releases/2010/03/100308220538.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins