Featured Research

from universities, journals, and other organizations

TWEAK triggers atrophy of disused muscle

Date:
March 22, 2010
Source:
Rockefeller University Press
Summary:
A new study identifies a cytokine signaling pathway that induces the breakdown of disused skeletal muscle. Blocking this pathway could prevent immobilized patients from losing their muscle tissue.

Muscle fibers grow smaller after denervation (left), but are protected when TWEAK activity is inhibited by a neutralizing antibody (right).
Credit: Mittal, A., et al. 2010. J. Cell Biol. doi:10.1083/jcb.200909117.

A new study in the Journal of Cell Biology (JCB) identifies a cytokine signaling pathway that induces the breakdown of disused skeletal muscle. Blocking this pathway could prevent immobilized patients from losing their muscle tissue.

The article appears in the March 22 issue of the JCB.

Skeletal muscle wastes away when its activity is reduced by, for example, a spinal cord injury. Although the mechanism by which muscle fibers break down is understood fairly well, how the process is triggered remains unknown. The TNF-related cytokine TWEAK can induce muscle loss, but whether it does so in disused muscle is unclear.

A team led by Ashok Kumar (University of Louisville School of Medicine, Kentucky) compared how mice expressing different amounts of TWEAK responded when the nerve innervating their hind legs was severed. Mice producing excess TWEAK lost their muscle more quickly than wild-type animals, whereas mice lacking this cytokine were largely protected from muscle breakdown. TWEAK levels also correlated with the amount of fibrosis, another common symptom of muscle disuse. Inhibiting TWEAK with a neutralizing antibody was sufficient to block muscle breakdown following the loss of motor neurons, suggesting that the pathway could be a viable therapeutic target.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Mittal, S. Bhatnagar, A. Kumar, E. Lach-Trifilieff, S. Wauters, H. Li, D. Y. Makonchuk, D. J. Glass, A. Kumar. The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. The Journal of Cell Biology, 2010; 188 (6): 833 DOI: 10.1083/jcb.200909117

Cite This Page:

Rockefeller University Press. "TWEAK triggers atrophy of disused muscle." ScienceDaily. ScienceDaily, 22 March 2010. <www.sciencedaily.com/releases/2010/03/100322091956.htm>.
Rockefeller University Press. (2010, March 22). TWEAK triggers atrophy of disused muscle. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2010/03/100322091956.htm
Rockefeller University Press. "TWEAK triggers atrophy of disused muscle." ScienceDaily. www.sciencedaily.com/releases/2010/03/100322091956.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins