Featured Research

from universities, journals, and other organizations

Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome

Date:
April 3, 2010
Source:
Emory University
Summary:
Four drugs used to treat HIV infection can inhibit a retrovirus recently linked to prostate cancer and chronic fatigue syndrome, researchers have shown. The findings suggest that if XMRV (xenotropic murine leukemia virus-related virus) is proven to be a cause for prostate cancer or chronic fatigue syndrome, those illnesses may be treatable with drugs already approved for treating HIV.

Four drugs used to treat HIV infection can inhibit a retrovirus recently linked to prostate cancer and chronic fatigue syndrome, researchers at Emory University/Atlanta Veterans Affairs Medical Center and the University of Utah have shown.

Related Articles


The results were published on April 1, 2010 by the journal PLoS ONE.

The findings suggest that if XMRV (xenotropic murine leukemia virus-related virus) is proven to be a cause for prostate cancer or chronic fatigue syndrome, those illnesses may be treatable with drugs already approved for treating HIV.

Discovered in 2006, XMRV has been detected in some prostate cancer patients' tumor biopsies by several investigators. However, its precise role in driving prostate cancer is unclear. A recent report (from the Whittemore Peterson Institute in Nevada) detected XMRV in a majority of chronic fatigue syndrome patients, but these results have not been confirmed by other laboratories.

"Not all studies that have looked for XMRV have been able to detect it in prostate cancers or in samples from chronic fatigue syndrome," says Ila Singh, MD, PhD, associate professor of pathology at the University of Utah School of Medicine. "We will need to see the results of clinical trials before these drugs can be used in a clinical setting."

Singh and Raymond Schinazi, PhD, DSc, professor of pediatrics and chemistry at Emory's Center for AIDS Research and the Atlanta VAMC, and colleagues teamed up to test 45 anti-HIV compounds, some of these discovered by Emory researchers, and other antiviral compounds against XMRV in cell culture.

The most potent drug against XMRV was raltegravir, produced by Merck and sold under the commercial name Isentress. The FDA initially approved raltegravir in 2007 only for persons whose HIV infection was resistant to other drugs, but in 2009 its approval was expanded to all HIV infected persons.

Raltegravir represents a new class of antiretroviral drugs because it inhibits the integrase enzyme, preventing the virus from invading a cell's DNA.

Other drugs against HIV inhibit either the reverse transcriptase enzyme, which copies the virus' genetic information, or the protease enzyme, which carves up newly produced viral proteins so that viruses can be assembled. However, none of the protease inhibitors inhibited XMRV in culture.

Besides raltegravir, three other compounds -- another integrase inhibitor and AZT and tenofovir DF, two reverse transcriptase inhibitors -- also inhibit XMRV replication. This suggests that these drugs could be used together in combination therapy, a particularly effective tactic against HIV that helps prevent the emergence of drug-resistant forms of the virus.

"Our study showed that these drugs inhibited XMRV at lower concentrations when two of them were used together, suggesting that highly potent 'cocktail' therapies might inhibit the virus from replicating and spreading," Schinazi says. "This combination of therapies might also have the added benefit of delaying or even preventing the virus from mutating into forms that are drug-resistant."

Although both XMRV and HIV are retroviruses, there is little similarity between HIV and XMRV at the protein level. Scientists have been able to show that several retroviruses cause cancer in animals, but only a few retroviruses are known to infect humans: human T-lymphotropic viruses 1 and 2, HIV, and now XMRV. Singh and Schinazi are now investigating the development of resistance in XMRV to raltegravir and other drugs.

Singh led a recently published study that demonstrated the presence of XMRV in 27 percent of prostate cancers examined, with the virus more likely to be found in the most-aggressive tumors. XMRV may promote cancer by integrating into the host cell DNA and warping the cell's regulation of its own genes.


Story Source:

The above story is based on materials provided by Emory University. The original article was written by Quinn Eastman. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ila R. Singh, John E. Gorzynski, Daria Drobysheva, Leda Bassit, Raymond F. Schinazi. Raltegravir Is a Potent Inhibitor of XMRV, a Virus Implicated in Prostate Cancer and Chronic Fatigue Syndrome. PLoS ONE, 2010; DOI: 10.1371/journal.pone.0009948

Cite This Page:

Emory University. "Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome." ScienceDaily. ScienceDaily, 3 April 2010. <www.sciencedaily.com/releases/2010/04/100401173724.htm>.
Emory University. (2010, April 3). Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/04/100401173724.htm
Emory University. "Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome." ScienceDaily. www.sciencedaily.com/releases/2010/04/100401173724.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins