Featured Research

from universities, journals, and other organizations

Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists

Date:
April 12, 2010
Source:
University of Liverpool
Summary:
Scientists in the UK have discovered that dangerous strains of Salmonella are beginning to emerge in people infected with HIV in Africa.

Scientists at the University of Liverpool have discovered that dangerous strains of Salmonella are beginning to emerge in people infected with HIV in Africa.

Related Articles


Their research has found that, in adults with HIV, new African Salmonellae can cause severe disease by invading cells in the blood and bone marrow, where they can hide away, allowing them to evolve into more dangerous, multi-drug resistant strains over time. This is made possible by the loss of immune cells that occurs in HIV which renders the body vulnerable to attack.

In Europe and the US, Salmonella normally causes diarrhoea and is rarely fatal, but in Africa, the new multi-drug resistant strains exploit vulnerable children and adults, causing severe infections that are difficult to treat and leading to death in one in four cases.

Previous work at the University of Liverpool in collaboration with the Wellcome Trust Sanger Institute, showed that new epidemic human strains of Salmonella are unique to Africa and have evolved to give a greater potential to cause serious disease. Researchers showed the strains, which were previously non-invasive, have now developed genetic similarities to the Salmonella bug that causes Typhoid Fever. This is significant because as well as being antibiotic resistant, their behaviour is likely to be intrinsically more invasive and aggressive than typical strains found in the US and Europe. This evolution has probably been driven by the context of the HIV epidemic.

The fact that the cells can persist inside cells in the blood and bone marrow confirms that these strains are behaving in a new and highly invasive fashion. It means that the infections are difficult to treat, and often persist and recur. This in turn means that conditions continue to be favourable for more bacterial adaptation, and for the evolution of more antibiotic resistance.

Dr Melita Gordon, Senior Lecturer and Consultant in Gastroenterology in the University of Liverpool, who carried out the work in partnership with Liverpool School of Tropical Medicine and the Malawi-Liverpool Wellcome Trust Major Overseas Unit, said: "This suggests that the high rate of HIV and other diseases that affect the immune system in Africa has provided an environmental niche in which new, more dangerous strains of Salmonella have been able to emerge.

"We are now studying ways in which these multi-drug resistant infections can be treated better without encouraging the emergence of newer forms of resistance to antibiotics. We should also be able to use the new genetic markers to track and understand the spread and habits of Salmonella in Africa much more effectively."

The research was funded by the Wellcome Trust and is published in Clinical Infectious Diseases.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. MelitaA. Gordon, AnsteadM.K. Kankwatira, Gershom Mwafulirwa, AmandaL. Walsh, MarkJ. Hopkins, ChristopherM. Parry, E.Brian Faragher, EduardE. Zijlstra, RobertS. Heyderman, MalcolmE. Molyneux. Invasive Non%u2010typhoid Salmonellae Establish Systemic Intracellular Infection in HIV%u2010Infected Adults: An Emerging Disease Pathogenesis. Clinical Infectious Diseases, 2010; 50 (7): 953 DOI: 10.1086/651080

Cite This Page:

University of Liverpool. "Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists." ScienceDaily. ScienceDaily, 12 April 2010. <www.sciencedaily.com/releases/2010/04/100412103708.htm>.
University of Liverpool. (2010, April 12). Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2010/04/100412103708.htm
University of Liverpool. "Prevalence of HIV in Africa is leading to new strains of Salmonella, say scientists." ScienceDaily. www.sciencedaily.com/releases/2010/04/100412103708.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins