Featured Research

from universities, journals, and other organizations

Gastroenterology: Putting your BEST(2) channel forward to maintain a healthy colon

Date:
April 19, 2010
Source:
Journal of Clinical Investigation
Summary:
Various diarrheal diseases, including the disease seen in some individuals with cystic fibrosis, is caused by disrupted transport of ions across the lining of the large intestine (the colon). Researchers have identified a new mechanism by which negatively charged ions are secreted into the colon in mice.

Various diarrheal diseases, including the disease seen in some individuals with cystic fibrosis, is caused by disrupted transport of ions across the lining of the large intestine (the colon). A team of researchers, led by Criss Hartzell, at Emory University School of Medicine, Atlanta, has identified a new mechanism by which negatively charged ions are secreted into the colon in mice.

Specifically, their data indicate that the protein BEST2 acts as a channel that allows bicarbonate (HCO3-) in the wall of the colon into the cells lining the colon and that it works with a protein that exchanges bicarbonate in the cell for chloride ions (Cl-) in the colon.

These data provide new insight into the mechanisms maintaining a healthy colon and suggest that dysregulated BEST2 function might contribute to the symptoms of inflammatory bowel diseases.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kuai Yu, Rafael Lujan, Alan Marmorstein, Sherif Gabriel and H. Criss Hartzell. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI41129

Cite This Page:

Journal of Clinical Investigation. "Gastroenterology: Putting your BEST(2) channel forward to maintain a healthy colon." ScienceDaily. ScienceDaily, 19 April 2010. <www.sciencedaily.com/releases/2010/04/100419233206.htm>.
Journal of Clinical Investigation. (2010, April 19). Gastroenterology: Putting your BEST(2) channel forward to maintain a healthy colon. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/04/100419233206.htm
Journal of Clinical Investigation. "Gastroenterology: Putting your BEST(2) channel forward to maintain a healthy colon." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419233206.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins