Featured Research

from universities, journals, and other organizations

Understanding how folic acid might help heal brain and spinal cord injuries

Date:
June 30, 2010
Source:
Journal of Clinical Investigation
Summary:
Babies born to women who do not consume enough folic acid are at high risk of developing neural tube defects. This is the reason underlying the recommendation that women who are pregnant take a folic acid supplement. New research using rodents now suggests how folic acid might also help promote healing in injured brain and spinal cord.

Babies born to women who do not consume enough folic acid (sometimes referred to as folate or vitamin B9) are at high risk of developing neural tube defects (i.e., defects in the development of the spinal cord or brain). This is the reason underlying the recommendation that women who are pregnant take a folic acid supplement.

A team of researchers, led by Bermans Iskandar, at the University of Wisconsin, Madison, has now generated data in rodents suggesting that folic acid might also help promote healing in injured brain and spinal cord.

Specifically, the team was able to uncover a molecular pathway by which folate can promote nerve cell regeneration following injury in rodents.

In an accompanying commentary, Matthias Endres and Golo Kronenberg, at Charité -- Universitätsmedizin Berlin, Germany, discuss how these data, together with the safety and simplicity of folate supplementation, provide a rationale for testing whether folate supplementation is beneficial for patients with spinal cord and brain trauma.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. bermans J. Iskandar, Elias Rizk, Brenton Meier, Nithya Hariharan, Teodoro Bottiglieri, Richard H. Finnell, David F. Jarrard, Ruma V. Banerjee, J.h. Pate Skene, Aaron Nelson, Nirav Patel, Carmen Gherasim, Kathleen Simon, Thomas D. Cook and Kirk J. Hogan. Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40000
  2. golo Kronenberg, and Matthias Endres. Neuronal injury: folate to the rescue? Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40764

Cite This Page:

Journal of Clinical Investigation. "Understanding how folic acid might help heal brain and spinal cord injuries." ScienceDaily. ScienceDaily, 30 June 2010. <www.sciencedaily.com/releases/2010/04/100426181708.htm>.
Journal of Clinical Investigation. (2010, June 30). Understanding how folic acid might help heal brain and spinal cord injuries. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/04/100426181708.htm
Journal of Clinical Investigation. "Understanding how folic acid might help heal brain and spinal cord injuries." ScienceDaily. www.sciencedaily.com/releases/2010/04/100426181708.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) — Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) — Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) — Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) — Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins