Featured Research

from universities, journals, and other organizations

Researchers reveal process of making ribs

Date:
April 29, 2010
Source:
Instituto Gulbenkian de Ciência (IGC)
Summary:
Like all vertebrates, snakes, mice and humans have in common a skeleton made of segments, the vertebrae. But a snake has between 200-400 ribs extending from all vertebrae, from the neck to the tail-end, whereas mice have only 13 pairs of ribs, and humans have 12 pairs, in both cases making up the ribcage. In a new study, researchers in Portugal reveal that, contrary to what was thought, making ribs is not the default state for vertebrates, but is actually an active process of balancing the activities of a remarkable class of genes -- the Hox genes.

Mice have a ribcage with 12 pairs of ribs (image on the left). When the gene Hox6 is activated in rib less regions of the embryo, extra ribs are formed, extending from the ribcage to the tail (image on the right).
Credit: Moises Mallo

Like all vertebrates, snakes, mice and humans have in common a skeleton made of segments, the vertebrae. But a snake has between 200-400 ribs extending from all vertebrae, from the neck to the tail-end, whereas mice have only 13 pairs of ribs, and humans have 12 pairs, in both cases making up the ribcage.

In the latest issue of Developmental Cell, researchers from the Instituto Gulbenkian de Ciência, in Portugal, reveal that, contrary to what was thought, making ribs is not the default state for vertebrates, but is actually an active process of balancing the activities of a remarkable class of genes -- the Hox genes.

It was thought that the rib less region of the mouse embryo was the result of a rib-inhibiting programme, driven by Hox10 genes. Indeed, previous studies, in which Hox10 genes were inactivated in the embryo, generated mice with extra ribs. However, by forcing another class of Hox genes (Hox6) to be activated in future rib-less regions of the mouse embryo, Moises Mallo and his team bred mice that also have extra ribs, both in the neck area, and from just after the rib cage, all the way down to the tail, resembling a snake-like skeleton.

"It was an extraordinary, and clear-cut result," says Mallo, "suggesting that these two groups of Hox genes balance each other out: one actively promotes rib formation to produce the thoracic region, while the other blocks this activity in the lumbar region. Our results have unveiled this balance."

The researchers went on to unpick the genes involved in this process, and came up with yet another surprising finding: that the whole process relies on first hitting so-called muscle genes in the embryo, which then provide signals to switch on the 'rib' genes to make both ribs and muscle, in a coordinated process.

According to Mallo, "Our findings reveal a more complicated process than we would have imagined, but one that makes perfect sense, from a functional and evolutionary point of view: it is no good to make ribs without muscle, so, in the embryo, the production of both ribs and their associated muscles is under the control of a single and coordinated mechanism."


Story Source:

The above story is based on materials provided by Instituto Gulbenkian de Ciência (IGC). Note: Materials may be edited for content and length.


Journal Reference:

  1. Tânia Vinagre, Natalia Moncaut, Marta Carapuço, Ana Nóvoa, Joana Bom, Moisés Mallo. Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains. Developmental Cell, 2010; 18 (4): 655 DOI: 10.1016/j.devcel.2010.02.011

Cite This Page:

Instituto Gulbenkian de Ciência (IGC). "Researchers reveal process of making ribs." ScienceDaily. ScienceDaily, 29 April 2010. <www.sciencedaily.com/releases/2010/04/100427071236.htm>.
Instituto Gulbenkian de Ciência (IGC). (2010, April 29). Researchers reveal process of making ribs. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2010/04/100427071236.htm
Instituto Gulbenkian de Ciência (IGC). "Researchers reveal process of making ribs." ScienceDaily. www.sciencedaily.com/releases/2010/04/100427071236.htm (accessed August 22, 2014).

Share This




More Plants & Animals News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) — According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) — According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com
Ramen Health Risks: The Dark Side of the Noodle

Ramen Health Risks: The Dark Side of the Noodle

AP (Aug. 21, 2014) — South Koreans eat more instant ramen noodles per capita than anywhere else in the world. But American researchers say eating too much may increase the risk of diabetes, heart disease and stroke. (Aug. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins