Featured Research

from universities, journals, and other organizations

Researchers help pinpoint osteoporosis genes

Date:
May 3, 2010
Source:
Jewish General Hospital
Summary:
Researchers have identified 20 genes associated with osteoporosis and bone weakness, including 13 genes never previously associated with the disease. Osteoporosis is a highly heritable trait, but this marks the largest international effort to conclusively identify genes linked to the often-devastating bone disorder.

A team of international researchers has identified 20 genes associated with osteoporosis and bone weakness, including 13 genes never previously associated with the disease. Osteoporosis is a highly heritable trait, but this marks the largest international effort to conclusively identify genes linked to the often-devastating bone disorder.

Related Articles


The study's co-first author is Dr. J. Brent Richards of the Lady Davis Institute for Medical Research at the Jewish General Hospital in Montreal, who collaborated with more than 30 co-authors worldwide. Their results were published recently in the journal Nature Genetics. The researchers reviewed data collected from nearly 20,000 individuals in five recent international genetic studies.

Osteoporosis reduces bone mineral density (BMD) and disrupts the microarchitecture of bone tissue, making bones more fragile and subject to fracture. The disease affects an estimated two million Canadians and 75 million people in the USA, Europe and Japan.

"Osteoporosis hip fractures alone cost $2.4 billion dollars per year in Canada in direct care," said Dr. Richards, a genetics researcher at the Lady Davis Institute and an assistant professor at McGill University's Faculty of Medicine. "Hip fractures are a common and costly condition which has a 50 percent mortality rate at two years, worse than some cancers."

Though it occurs in people of all ethnic groups, the lion's share of the osteoporosis burden falls on post-menopausal women of European and Asian descent. According to the International Osteoporosis Foundation (IOF), one in three women over the age of 50 will experience osteoporotic fractures, as will one in five men. By 2050 the worldwide incidence of hip fracture is projected to increase by 310 percent in men and 240 percent in women.

"We were able to look across the whole human genome to try to identify which genes -- of all the genes that we inherit -- that seem to be responsible for osteoporosis," Dr. Richards explained. "Not only did we find 13 entirely new genes, we also demonstrated that some of these genes were related not just to bone density, but also to fracture risk itself."

Richards is optimistic that these results will bring practical benefits to patients.

"In order to better treat any condition, we need to know what causes it," he said. "We knew that one of the strongest factors in osteoporosis was genetic, but we didn't have a clear picture what those genetic factors were. This study affords us the opportunity to study the genetic mechanisms which control bone strength, and to intervene to prevent peoples' bones from getting weak. Also, if we are able to uncover more genes which influence bone strength, then we may be able to identify whole populations that require early preventive treatment."


Story Source:

The above story is based on materials provided by Jewish General Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fernando Rivadeneira, Unnur Styrkársdottir, Karol Estrada, Bjarni V Halldórsson, Yi-Hsiang Hsu, J Brent Richards, M Carola Zillikens, Fotini K Kavvoura, Najaf Amin, Yurii S Aulchenko, L Adrienne Cupples, Panagiotis Deloukas, Serkalem Demissie, Elin Grundberg, Albert Hofman, Augustine Kong, David Karasik, Joyce B van Meurs, Ben Oostra, Tomi Pastinen, Huibert A P Pols, Gunnar Sigurdsson, Nicole Soranzo, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Frances M K Williams, Scott G Wilson, Yanhua Zhou, Stuart H Ralston, Cornelia M van Duijn, Timothy Spector, Douglas P Kiel, Kari Stefansson, John P A Ioannidis, André G Uitterlinden. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nature Genetics, 2009; 41 (11): 1199 DOI: 10.1038/ng.446

Cite This Page:

Jewish General Hospital. "Researchers help pinpoint osteoporosis genes." ScienceDaily. ScienceDaily, 3 May 2010. <www.sciencedaily.com/releases/2010/05/100503135709.htm>.
Jewish General Hospital. (2010, May 3). Researchers help pinpoint osteoporosis genes. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/05/100503135709.htm
Jewish General Hospital. "Researchers help pinpoint osteoporosis genes." ScienceDaily. www.sciencedaily.com/releases/2010/05/100503135709.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) — The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins