Featured Research

from universities, journals, and other organizations

Properties of insulin reduce inflammation caused by obesity, lower risk of type 2 diabetes, research finds

Date:
May 10, 2010
Source:
University of Gothenburg
Summary:
Recent decades have seen a huge increase in type 2 diabetes and cardiovascular disease. This is a result of people being less active and eating fattier diets, which can lead to obesity and, in turn, diabetes. Researchers in Sweden have discovered properties of insulin which reduce inflammation caused by obesity and can therefore lower the risk of type 2 diabetes.

Recent decades have seen a huge increase in type 2 diabetes and cardiovascular disease. This is a result of people being less active and eating fattier diets, which can lead to obesity and, in turn, diabetes. In a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden, researchers have discovered properties of insulin which reduce inflammation caused by obesity and can therefore lower the risk of type 2 diabetes.

When you put on weight, your fat tissue grows and begins to produce a wealth of inflammatory molecules. The increase in these inflammatory molecules leaves the fat tissue in a state of chronic inflammation. This plays an important role in the development of insulin resistance, an early stage of type 2 diabetes, where the body is unable to regulate blood sugar levels using its own insulin.

"It's still not entirely clear why obesity causes insulin resistance," says Emelie Wallerstedt from the Institute of Medicine at the University of Gothenburg. "Inflammation could be part of the reason why obesity leads to type 2 diabetes."

Research has shown that both obesity and insulin resistance are affected by inflammatory conditions in the body. Previously it was believed that fat tissue served merely as a depository for fat, but now scientists know that it is also an important organ for the release of a wide range of different substances, including inflammatory molecules. In the thesis, the researchers managed to identify the properties of the inflammatory molecule IL-6.

"IL-6 impairs insulin signalling, but the insulin signalling itself can also inhibit and 'turn off' the IL-6 signal and inflammation," says Wallerstedt. "The protein PKCdelta also plays an important role in the regulation of the IL-6 signal, and we have shown that if we disable the function of this molecule, the inflammation decreases."

A greater understanding of these signalling mechanisms could make it possible in the future to develop medicines that can "turn off" the inflammation and so reduce the risk of insulin resistance and other obesity-related disorders.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Wallerstedt, U. Smith, C. X. Andersson. Protein kinase C-δ is involved in the inflammatory effect of IL-6 in mouse adipose cells. Diabetologia, 2010; 53 (5): 946 DOI: 10.1007/s00125-010-1668-1

Cite This Page:

University of Gothenburg. "Properties of insulin reduce inflammation caused by obesity, lower risk of type 2 diabetes, research finds." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100509202647.htm>.
University of Gothenburg. (2010, May 10). Properties of insulin reduce inflammation caused by obesity, lower risk of type 2 diabetes, research finds. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/05/100509202647.htm
University of Gothenburg. "Properties of insulin reduce inflammation caused by obesity, lower risk of type 2 diabetes, research finds." ScienceDaily. www.sciencedaily.com/releases/2010/05/100509202647.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins