Featured Research

from universities, journals, and other organizations

Better animal-free test for chemicals that can cause contact dermatitis

Date:
June 1, 2010
Source:
American Chemical Society
Summary:
Scientists are reporting development of a fast, simple, inexpensive method for determining whether chemicals in consumer products and workplaces may cause skin allergies in people -- a method that does not involve use of animals.

A fast, simple, inexpensive method has been developed for determining whether chemicals in consumer products and workplaces may cause skin allergies in people
Credit: iStockphoto/Heike Kampe

Scientists are reporting development of a fast, simple, inexpensive method for determining whether chemicals in consumer products and workplaces may cause skin allergies in people -- a method that does not involve use of animals.

Related Articles


Their study appears in ACS' Chemical Research in Toxicology, a monthly journal.

Itai Chipinda and his colleagues note the existence of public sentiment against the use of animals to determine whether ingredients in consumer soaps, shampoos and other consumer products, and workplace chemicals, may cause skin sensitization and contact dermatitis. Chemicals cause dermatitis by bonding to proteins in the skin, and then aggravating the immune system so that redness, irritation, itching, and other symptoms occur.

Existing chemical tests use substances like glutathione that mimic skin proteins and bond to allergy-causing ingredients. None, however, are suitable for use in detecting the critical early stages of skin sensitization, the scientists say.

Instead of glutathione, Chipinda and his team developed a test with nitrobenzenethiol as the skin protein surrogate. When used on 20 different chemicals known to cause skin irritation, the test produced positive results. It produced negative results when used to test substances that usually do not produce skin sensitization.

"This simple, rapid and inexpensive absorbance-based method has great potential for use as a preliminary screening tool for skin allergens," the report states.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Itai Chipinda, Risikat O. Ajibola, Moshood K. Morakinyo, Tinashe B. Ruwona, Reuben H. Simoyi, Paul D. Siegel. Rapid and Simple Kinetics Screening Assay for Electrophilic Dermal Sensitizers Using Nitrobenzenethiol. Chemical Research in Toxicology, 2010; 23 (5): 918 DOI: 10.1021/tx100003w

Cite This Page:

American Chemical Society. "Better animal-free test for chemicals that can cause contact dermatitis." ScienceDaily. ScienceDaily, 1 June 2010. <www.sciencedaily.com/releases/2010/05/100526124717.htm>.
American Chemical Society. (2010, June 1). Better animal-free test for chemicals that can cause contact dermatitis. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2010/05/100526124717.htm
American Chemical Society. "Better animal-free test for chemicals that can cause contact dermatitis." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526124717.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins