Featured Research

from universities, journals, and other organizations

Peaches, plums induce deliciously promising death of breast cancer cells

Date:
June 2, 2010
Source:
Texas A&M AgriLife Communications
Summary:
Breast cancer cells -- even the most aggressive type -- died after treatments with peach and plum extracts in lab tests in Texas recently, and scientists say the results are deliciously promising. Not only did the cancerous cells keel over, but the normal cells were not harmed in the process.

Breast cancer cells -- even the most aggressive type -- died after treatments with peach and plum extracts in lab tests at Texas AgriLife Research.
Credit: Photo courtesy of U.S. Department of Agriculture-Agriculture Research Service

Breast cancer cells -- even the most aggressive type -- died after treatments with peach and plum extracts in lab tests at Texas AgriLife Research recently, and scientists say the results are deliciously promising. Not only did the cancerous cells keel over, but the normal cells were not harmed in the process.

Related Articles


AgriLife Research scientists say two phenolic compounds are responsible for the cancer cell deaths in the study, which was published in the Journal of Agriculture and Food Chemistry. The phenols are organic compounds that occur in fruits. They are slightly acidic and may be associated with traits such as aroma, taste or color.

"It was a differential effect which is what you're looking for because in current cancer treatment with chemotherapy, the substance kills all cells, so it is really tough on the body," said Dr. David Byrne, AgriLife Research plant breeder who studies stone fruit. "Here, there is a five-fold difference in the toxic intensity. You can put it at a level where it will kill the cancer cells -- the very aggressive ones -- and not the normal ones."

Byrne and Dr. Luis Cisneros-Zevallos originally studied the antioxidants and phytonutrients in plums and found them to match or exceed the blueberry which had been considered superior to other fruits in those categories.

"The following step was to choose some of these high antioxidant commercial varieties and study their anticancer properties," Cisneros-Zevallos said. "And we chose breast cancer as the target because it's one of the cancers with highest incidence among women. So it is of big concern."

According to the National Cancer Institute, there were 192,370 new cases of breast cancer in females and 1,910 cases in males in 2009. That year, 40,170 women and 440 men died from breast cancer. The World Health Organization reports that breast cancer accounts for 16 percent of the cancer deaths of women globally.

Cisneros-Zevallos, an AgriLife Research food scientist, said the team compared normal cells to two types of breast cancer, including the most aggressive type. The cells were treated with an extract from two commercial varieties, the "Rich Lady" peach and the "Black Splendor" plum.

"These extracts killed the cancer cells but not the normal cells," Cisneros-Zevallos said.

A closer look at the extracts determined that two specific phenolic acid components -- chlorogenic and neochlorogenic -- were responsible for killing the cancer cells while not affecting the normal cells, Cisneros-Zevallos said.

The two compounds are very common in fruits, the researchers said, but the stone fruits such as plums and peaches have especially high levels.

"So this is very, very attractive from the point of view of being an alternative to typical chemotherapy which kills normal cells along with cancerous ones," Byrne added.

The team said laboratory tests also confirmed that the compounds prevented cancer from growing in animals given the compounds.

Byrne plans to examine more fully the lines of the varieties that were tested to see how these compounds might be incorporated into his research of breeding plums and peaches. Cisneros-Zevallos will continue testing these extracts and compounds in different types of cancer and conduct further studies of the molecular mechanisms involved.

The work documenting the health benefits of stone fruit has been supported by the Vegetable and Fruit Improvement Center at Texas A&M University, the U.S. Department of Agriculture and the California Tree Fruit Agreement.


Story Source:

The above story is based on materials provided by Texas A&M AgriLife Communications. The original article was written by Kathleen Phillips. Note: Materials may be edited for content and length.


Journal Reference:

  1. Giuliana Noratto, Weston Porter, David Byrne, Luis Cisneros-Zevallos. Identifying Peach and Plum Polyphenols with Chemopreventive Potential against Estrogen-Independent Breast Cancer Cells. Journal of Agricultural and Food Chemistry, 2009; 57 (12): 5219 DOI: 10.1021/jf900259m

Cite This Page:

Texas A&M AgriLife Communications. "Peaches, plums induce deliciously promising death of breast cancer cells." ScienceDaily. ScienceDaily, 2 June 2010. <www.sciencedaily.com/releases/2010/06/100602111145.htm>.
Texas A&M AgriLife Communications. (2010, June 2). Peaches, plums induce deliciously promising death of breast cancer cells. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2010/06/100602111145.htm
Texas A&M AgriLife Communications. "Peaches, plums induce deliciously promising death of breast cancer cells." ScienceDaily. www.sciencedaily.com/releases/2010/06/100602111145.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins