Featured Research

from universities, journals, and other organizations

Detection of MRSA in cystic fibrosis patients associated with shorter survival

Date:
June 17, 2010
Source:
Case Western Reserve University
Summary:
Patients with cystic fibrosis who have Methicillin-resistant Staphylococcus aureus (MRSA) detected in their respiratory tract have worse survival compared to CF patients without MRSA, according to a new study.

Patients with cystic fibrosis who have Methicillin-resistant Staphylococcus aureus (MRSA) detected in their respiratory tract have worse survival compared to CF patients without MRSA, according to a new study.

A team of researchers led by Elliott Dasenbrook, MD, MHS, Assistant Professor of Medicine and Pediatrics at Case Western Reserve University School of Medicine and Associate Director of the Adult Cystic Fibrosis Program at University Hospitals Case Medical Center's Rainbow Babies & Children's Hospital published the findings from their study in the June 16 issue of JAMA.

Specifically, the study observed patients with CF who had MRSA detected in their respiratory tract. Results show these patients have worse survival, approximately 1.3 times greater risk of death, compared to CF patients without MRSA. Dr. Dasenbrook's team, including co-author Michael Konstan, MD, Chairman of the Department of Pediatrics at University Hospitals Case Medical Center's Rainbow Babies & Children's Hospital and Case Western Reserve University School of Medicine, studied more than 19,000 patients with CF to reach their conclusions.

The most common cause of death in CF is respiratory failure secondary to pulmonary infection. The prevalence of MRSA in the respiratory tract of individuals with CF has increased substantially in the past five years, and is now more than 20 percent (higher in urban areas) according to the article.

"Our study findings may prompt many doctors to reconsider how they care for CF patients," says Dr. Dasenbrook. He adds, "Until now, some doctors weren't aggressively treating patients with MRSA. Doctors often viewed MRSA to not be as important as other respiratory-tract infections. With our study findings, treatment patterns may change as the risk of death is 1.3 times greater for CF patients with MRSA."

Dr. Konstan elaborates, "Identifying a specific risk factor like MRSA for shortened survival for a disease like CF provides a target for future research and clinical intervention."

The study included 19,833 CF patients (ages 6 to 45 years) who were tracked in the United States' Cystic Fibrosis Foundation Patient Registry between January 1996 and December 2006, with follow-up until December 2008. Various analytic models were used to compare survival between CF patients with and without respiratory tract MRSA.

During the study period, 2,537 patients died and 5,759 individuals had respiratory tract MRSA detected. The mortality rate was 18.3 deaths per 1,000 patient-years for patients without MRSA and 27.7 deaths per 1,000 patient-years for those with MRSA. After adjustment for various factors associated with severity of illness, the risk of death was approximately 1.3 times greater for CF patients when MRSA was detected compared with when MRSA was not detected.

The results of this study, in conjunction with previous data, further establish MRSA as a significant CF pathogen and provide impetus for more aggressive treatment of CF patients who are persistently MRSA positive. Ideally this treatment will be conducted in the context of clinical trials, because optimal therapeutic approaches for MRSA, both persistent and new, are not yet known.

"The findings from our study will drive how treatment of MRSA will be conducted in the future. Optimal approaches now are not yet known and we are currently designing a trial to eradicate MRSA from CF patients with the ultimate goal of prolonging their life," Dr. Dasenbrook says.

The study results also reinforce the importance of following current CF infection control guidelines to minimize transmission of MRSA, particularly in outpatient clinics with high CF patient volume.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Elliott C. Dasenbrook; William Checkley; Christian A. Merlo; Michael W. Konstan; Noah Lechtzin; Michael P. Boyle. Association Between Respiratory Tract Methicillin-Resistant Staphylococcus aureus and Survival in Cystic Fibrosis. JAMA, 2010; 303 (23): 2386-2392 [link]

Cite This Page:

Case Western Reserve University. "Detection of MRSA in cystic fibrosis patients associated with shorter survival." ScienceDaily. ScienceDaily, 17 June 2010. <www.sciencedaily.com/releases/2010/06/100615163129.htm>.
Case Western Reserve University. (2010, June 17). Detection of MRSA in cystic fibrosis patients associated with shorter survival. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/06/100615163129.htm
Case Western Reserve University. "Detection of MRSA in cystic fibrosis patients associated with shorter survival." ScienceDaily. www.sciencedaily.com/releases/2010/06/100615163129.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins