Featured Research

from universities, journals, and other organizations

New way to slow the growth of malignant melanoma

Date:
July 9, 2010
Source:
Queen's University
Summary:
New research has shown that the growth of melanoma, one of the most deadly forms of skin cancer, can be slowed when a little known gene called microRNA 193b is added.

New research from Queen's University in Canada has shown that the growth of melanoma, one of the most deadly forms of skin cancer, can be slowed when a little known gene called MicroRNA 193b is added.

Victor Tron, head of pathology and molecular medicine, focused on miR-193b when he discovered that it was deficient in melanoma tumors and because there were very few studies done about the gene. The miRNA-193b gene is found in people's DNA and was unknown until 10 years ago.

"Our experiment was a bit of a fishing expedition in the beginning. We thought 193b might be important but the fact we got such a tremendous reaction -- the melanoma really slowed down when we added 193b -- was really startling," says Dr. Tron, who worked with eight other Queen's researchers. "It's a totally new discovery."

In experiments, increased levels of miR-193b increased in melanoma cells led to lower levels of a well-known protein called cyclin D1, and decreased melanoma cell growth.

Lab experiments with tissue samples proved that miR-193b plays a role in the melanoma process. Further studies will be needed to find out what causes miR-193b levels to go up and down.

"This is the first step in a long road towards finding a melanoma cure," says Professor Tron.

Melanoma is one of the least common forms of skin cancer, yet causes 75 per cent of skin cancer deaths.

The study was recently published in the American Journal of Pathology. Pathology researchers Harriet Feilotter, Genevieve Pare, Xiao Zhang, Joshua Pemberton, Cherif Grady, Dulcie Lai and Xiaolong Yang and graduate student Jiamin Chen were also on the research team.


Story Source:

The above story is based on materials provided by Queen's University. Note: Materials may be edited for content and length.


Cite This Page:

Queen's University. "New way to slow the growth of malignant melanoma." ScienceDaily. ScienceDaily, 9 July 2010. <www.sciencedaily.com/releases/2010/07/100708111332.htm>.
Queen's University. (2010, July 9). New way to slow the growth of malignant melanoma. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/07/100708111332.htm
Queen's University. "New way to slow the growth of malignant melanoma." ScienceDaily. www.sciencedaily.com/releases/2010/07/100708111332.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins