Featured Research

from universities, journals, and other organizations

New way diseases can develop: Previously unknown mechanism directs gene expression in cells

Date:
July 9, 2010
Source:
The Mount Sinai Hospital / Mount Sinai School of Medicine
Summary:
Researchers have identified a previously unknown mechanism by which cells direct gene expression, the process by which information from a gene is used to direct the physical and behavioral development of individuals. The research may help scientists gain insight into how muscle and heart diseases develop.

Researchers from Mount Sinai School of Medicine have identified a previously unknown mechanism by which cells direct gene expression, the process by which information from a gene is used to direct the physical and behavioral development of individuals.

Related Articles


The research, which may help scientists gain insight into how muscle and heart diseases develop, is published in the July 8th issue of Nature.

Using a combined approach of structural and molecular biology, a team of researchers led by Ming-Ming Zhou, PhD, Professor and Chair, Structural and Chemical Biology, Mount Sinai School of Medicine, determined that the molecular interactions between proteins are very different than previously thought, and that they play an essential role in the initiation of gene transcription of muscle and the heart. Gene transcription is the first step to gene expression, a cellular process that occurs in response to physiological and environmental stimuli, and is dictated by chemical modifications of the DNA and histones, which are the proteins responsible for packaging the DNA.

Dr. Zhou's team found a new fundamental mechanism in gene transcription through a protein called DPF3b. They learned that DPF3b recognizes gene-activating chemical marks in these histones in a very different way. DPF3b plays a critical role in the copying of genes -- a crucial part of the transcription process -- for muscle growth and heart development.

"This discovery opens new doors in genome biology research, and has broad implications in the field of epigenetics of human biology of health and disease," said Martin Walsh, PhD, Associate Professor, Pediatrics, and Structural and Chemical Biology at Mount Sinai who is also a co-author of the study. "Knowing that there is an additional way our genome is regulated will allow us to understand the molecular basis of certain human disorders that result from dysregulation of gene expression."

Dr. Zhou said that bromodomains, which are housed in proteins, read off cell signals that turn on genes that determine genetic makeup. "This study uncovers that nature has an alternative to bromodomains for gene expression to initiate, providing a new mechanism to help us understand how our muscles and heart grow properly, and what might cause them to grow abnormally," Dr. Zhou said.


Story Source:

The above story is based on materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lei Zeng, Qiang Zhang, SiDe Li, Alexander N. Plotnikov, Martin J. Walsh, Ming-Ming Zhou. Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature, 2010; 466 (7303): 258 DOI: 10.1038/nature09139

Cite This Page:

The Mount Sinai Hospital / Mount Sinai School of Medicine. "New way diseases can develop: Previously unknown mechanism directs gene expression in cells." ScienceDaily. ScienceDaily, 9 July 2010. <www.sciencedaily.com/releases/2010/07/100708152101.htm>.
The Mount Sinai Hospital / Mount Sinai School of Medicine. (2010, July 9). New way diseases can develop: Previously unknown mechanism directs gene expression in cells. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2010/07/100708152101.htm
The Mount Sinai Hospital / Mount Sinai School of Medicine. "New way diseases can develop: Previously unknown mechanism directs gene expression in cells." ScienceDaily. www.sciencedaily.com/releases/2010/07/100708152101.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins