Featured Research

from universities, journals, and other organizations

New method helps nerves grow after trauma or injury

Date:
July 12, 2010
Source:
University of Calgary
Summary:
Scientists have discovered a way to enhance nerve regeneration in the peripheral nervous system. The finding could lead to new treatments for nerve damage caused by diabetes or traumatic injuries. Peripheral nerves connect the brain and spinal cord to the body, and without them, there is no movement or sensation. Peripheral nerve damage is common and often irreversible.

University of Calgary scientists have discovered a way to enhance nerve regeneration in the peripheral nervous system. The finding could lead to new treatments for nerve damage caused by diabetes or traumatic injuries. Peripheral nerves connect the brain and spinal cord to the body, and without them, there is no movement or sensation. Peripheral nerve damage is common and often irreversible.

Related Articles


The research is published in the July 7, 2010 edition of the Journal of Neuroscience.

Senior researcher on the study, Dr. Douglas Zochodne, is a neurologist and professor in the Department of Clinical Neurosciences. Kimberly Christie, lead author on the study and a PhD student in Dr. Zochodne's lab, along with Hotchkiss Brain Institute colleagues, used a rat model to examine a pathway that helps nerves to grow and survive. Within this pathway is a molecular brake, called PTEN, that helps to prevent excessive cell growth under normal conditions.

In addition to discovering for the first time that PTEN is found in the peripheral nervous system, Zochodne's team demonstrated that following nerve injury, PTEN prevents peripheral nerves from regenerating. The team was able to block PTEN, an approach that dramatically increased nerve outgrowth.

Kimberly Christie says, "We were amazed to see such a dramatic effect over such a short time period. No one knew that nerves in the peripheral system could regenerate in this way, nerves that can be damaged if someone has diabetes for example. This finding could eventually help people who have lost feeling or motor skills recover and live with less pain."

Peripheral nerve damage can lead to pain, tingling, numbness or difficulty coordinating hands, feet, arms or legs. This can happen with diseases like diabetes, an injury due to a crushed or cut nerve, or other conditions known as neuropathy.

"Removing the brakes on regeneration offers us a new approach. Our next steps will be to find out if the exciting rise in nerve outgrowth we have observed will result in long term benefits," says Zochodne.

This research was supported by the Canadian Institutes of Health Research, Alberta Innovates -- Health Solutions (funded by the Alberta Heritage Foundation for Medical Research Endowment Fund) and the National Science and Engineering Research Council.


Story Source:

The above story is based on materials provided by University of Calgary. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kimberly J. Christie, Christine A. Webber, Jose A. Martinez, Bhagat Singh, and Douglas W. Zochodne. PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons. Journal of Neuroscience, 2010; DOI: 10.1523/JNEUROSCI.6271-09.2010

Cite This Page:

University of Calgary. "New method helps nerves grow after trauma or injury." ScienceDaily. ScienceDaily, 12 July 2010. <www.sciencedaily.com/releases/2010/07/100712102802.htm>.
University of Calgary. (2010, July 12). New method helps nerves grow after trauma or injury. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/07/100712102802.htm
University of Calgary. "New method helps nerves grow after trauma or injury." ScienceDaily. www.sciencedaily.com/releases/2010/07/100712102802.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins