Featured Research

from universities, journals, and other organizations

Simple screening test reduces invasive examinations for suspected bowel disease

Date:
July 23, 2010
Source:
BMJ-British Medical Journal
Summary:
A simple screening test identifies patients who are most likely to have inflammatory bowel disease and reduces the need for expensive, invasive and time consuming endoscopies, finds a new study.

A simple screening test identifies patients who are most likely to have inflammatory bowel disease and reduces the need for expensive, invasive and time consuming endoscopies, finds a study published online in the British Medical Journal.

Endoscopy is a procedure that involves passing a camera on the end of a flexible tube through the rectum to examine the bowel.

Rates of inflammatory bowel disease are rising in both adults and children. The major types are Crohn's disease and ulcerative colitis and symptoms can include abdominal pain, diarrhoea, rectal bleeding and weight loss.

A diagnosis is generally made using endoscopy and taking small tissue samples (biopsies), but this process is expensive, invasive and time consuming and, for many patients, the results are negative.

A simple, non-invasive and cheap screening test would help doctors identify patients who are most likely to have inflammatory bowel disease and thus avoid unnecessary endoscopies in other patients.

Measuring calprotectin levels (a protein found in inflammatory cells) in stools could be a good screening test, but its accuracy is largely unknown.

So researchers based in the Netherlands set out to determine whether faecal calprotectin can serve as a screening test to limit the number of people undergoing invasive endoscopy.

They analysed the results of six adult (670 patients) and seven child studies (371 patients) comparing faecal calprotectin with endoscopy in patients with suspected inflammatory bowel disease.

Inflammatory bowel disease was confirmed in 32% of the adults and 61% of the children

Screening with faecal calprotectin reduced the number of endoscopies by 67% in adults and 35% in children, but it also delayed diagnosis in 6% (2 in 32) of the affected adults and 8% (5 in 61) of the affected children.

The clinical consequences of missing patients with inflammatory bowel disease should be balanced against those patients without the disease who are subjected to endoscopy, say the authors.

Despite some differences in the design and quality of the studies, they conclude that faecal calprotectin is a useful screening tool for identifying patients who are most likely to need endoscopic evaluation for suspected inflammatory bowel disease.

The ability of the test to safely exclude inflammatory bowel disease (its specificity) is significantly better in adult studies than in paediatric studies, they add.

In an accompanying editorial, Robert Logan, consultant gastroenterologist at Kings College Hospital in London says that these findings support more widespread use of the test in secondary care, but that there is not yet enough evidence to support its use in primary care.

"If studies conducted in primary care find a high diagnostic accuracy of the faecal calprotectin test it will be an important step forward in how inflammatory bowel disease is diagnosed," he writes.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Simple screening test reduces invasive examinations for suspected bowel disease." ScienceDaily. ScienceDaily, 23 July 2010. <www.sciencedaily.com/releases/2010/07/100715194415.htm>.
BMJ-British Medical Journal. (2010, July 23). Simple screening test reduces invasive examinations for suspected bowel disease. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/07/100715194415.htm
BMJ-British Medical Journal. "Simple screening test reduces invasive examinations for suspected bowel disease." ScienceDaily. www.sciencedaily.com/releases/2010/07/100715194415.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins