Featured Research

from universities, journals, and other organizations

Simple screening test reduces invasive examinations for suspected bowel disease

Date:
July 23, 2010
Source:
BMJ-British Medical Journal
Summary:
A simple screening test identifies patients who are most likely to have inflammatory bowel disease and reduces the need for expensive, invasive and time consuming endoscopies, finds a new study.

A simple screening test identifies patients who are most likely to have inflammatory bowel disease and reduces the need for expensive, invasive and time consuming endoscopies, finds a study published online in the British Medical Journal.

Endoscopy is a procedure that involves passing a camera on the end of a flexible tube through the rectum to examine the bowel.

Rates of inflammatory bowel disease are rising in both adults and children. The major types are Crohn's disease and ulcerative colitis and symptoms can include abdominal pain, diarrhoea, rectal bleeding and weight loss.

A diagnosis is generally made using endoscopy and taking small tissue samples (biopsies), but this process is expensive, invasive and time consuming and, for many patients, the results are negative.

A simple, non-invasive and cheap screening test would help doctors identify patients who are most likely to have inflammatory bowel disease and thus avoid unnecessary endoscopies in other patients.

Measuring calprotectin levels (a protein found in inflammatory cells) in stools could be a good screening test, but its accuracy is largely unknown.

So researchers based in the Netherlands set out to determine whether faecal calprotectin can serve as a screening test to limit the number of people undergoing invasive endoscopy.

They analysed the results of six adult (670 patients) and seven child studies (371 patients) comparing faecal calprotectin with endoscopy in patients with suspected inflammatory bowel disease.

Inflammatory bowel disease was confirmed in 32% of the adults and 61% of the children

Screening with faecal calprotectin reduced the number of endoscopies by 67% in adults and 35% in children, but it also delayed diagnosis in 6% (2 in 32) of the affected adults and 8% (5 in 61) of the affected children.

The clinical consequences of missing patients with inflammatory bowel disease should be balanced against those patients without the disease who are subjected to endoscopy, say the authors.

Despite some differences in the design and quality of the studies, they conclude that faecal calprotectin is a useful screening tool for identifying patients who are most likely to need endoscopic evaluation for suspected inflammatory bowel disease.

The ability of the test to safely exclude inflammatory bowel disease (its specificity) is significantly better in adult studies than in paediatric studies, they add.

In an accompanying editorial, Robert Logan, consultant gastroenterologist at Kings College Hospital in London says that these findings support more widespread use of the test in secondary care, but that there is not yet enough evidence to support its use in primary care.

"If studies conducted in primary care find a high diagnostic accuracy of the faecal calprotectin test it will be an important step forward in how inflammatory bowel disease is diagnosed," he writes.


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

BMJ-British Medical Journal. "Simple screening test reduces invasive examinations for suspected bowel disease." ScienceDaily. ScienceDaily, 23 July 2010. <www.sciencedaily.com/releases/2010/07/100715194415.htm>.
BMJ-British Medical Journal. (2010, July 23). Simple screening test reduces invasive examinations for suspected bowel disease. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/07/100715194415.htm
BMJ-British Medical Journal. "Simple screening test reduces invasive examinations for suspected bowel disease." ScienceDaily. www.sciencedaily.com/releases/2010/07/100715194415.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins