Featured Research

from universities, journals, and other organizations

Long-sought ligand for receptors on precursor B cells discovered

Date:
July 16, 2010
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Scientists have discovered a new mechanism that drives the development of B-lymphocytes in our bone marrow. B-lymphocytes are an important part of our immune system. Upon their activation they produce the antibodies protecting us from infections.

The pre-B cell receptor (pre-BCR), a receptor that carries its own ligand.
Credit: Image courtesy of Albert-Ludwigs-Universität Freiburg

Scientists from the Department of Molecular Immunology, Institute of Biology III, Faculty of Biology and the Centre for Biological Signalling Studies, BIOSS, have discovered a new mechanism that drives the development of B-lymphocytes in our bone marrow.

Related Articles


B-lymphocytes are an important part of our immune system. Upon their activation they produce the antibodies protecting us from infections. Each day a human body produces one billion new B cells. Their development starts from hematopoietic stem cells and passes through a precursor B cell stage (pre-B cells) in the bone marrow where early B cells are expanded and selected. For their proper development pre-B cells require the expression and signaling function of the so-called pre-B cell receptor (pre-BCR). A failure to produce a functional pre-BCR results in the arrest of B cell development and a severe B cell immunodeficiency.

An older finding was that in contrast to the B cell antigen receptor (BCR) on mature B cells the pre-BCR is constitutively signaling on pre-B cells. This initiated a search for the ligand of this receptor that was assumed to be expressed by other cells of the bone marrow environment. However, it also had been found earlier that the pre-BCR retained its constitutive signaling even on isolated pre-B cells.

The group headed by Dr. Hassan Jumaa has now found a solution to this long standing puzzle. They discovered that the pre-BCR carries its own ligand in form of a sugar group attached to the heavy chain of the receptor. Specifically, they showed that by genetically removing this particular glycogroup the pre-BCR is loosing its continuous signaling behaviour.

"Finding the ligand as part of the pre-BCR is somewhat like finding a treasure in your front garden that everybody else was hunting in remote parts of the world," says Rudolf Uebelhart, the first author of the publication and a PhD student funded by the Speeman graduate school of Biology and Medicine (SGBM).


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rudolf Übelhart, Martina P. Bach, Cathrin Eschbach, Thomas Wossning, Michael Reth and Hassan Jumaa. Autonomous pre-BCR function requires a specific N-linked glycosylation site in the heavy chain. Nature Immunology, 2010; DOI: 10.1038/ni.1903

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "Long-sought ligand for receptors on precursor B cells discovered." ScienceDaily. ScienceDaily, 16 July 2010. <www.sciencedaily.com/releases/2010/07/100716125411.htm>.
Albert-Ludwigs-Universität Freiburg. (2010, July 16). Long-sought ligand for receptors on precursor B cells discovered. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2010/07/100716125411.htm
Albert-Ludwigs-Universität Freiburg. "Long-sought ligand for receptors on precursor B cells discovered." ScienceDaily. www.sciencedaily.com/releases/2010/07/100716125411.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins