Featured Research

from universities, journals, and other organizations

Identification of a gene essential to newborn babies' first breath

Date:
July 23, 2010
Source:
CNRS (Délégation Paris Michel-Ange)
Summary:
How do mammals prepare themselves in utero for a radical modification to their respiration at the time of birth, when they move abruptly from an aquatic medium to air? Researchers have identified a gene in the mouse that is essential to respiration and consequently to survival at birth. This work opens the way to better understanding respiratory disorders in humans, which can range from sleep apnea to sudden infant death syndrome.

How do mammals prepare themselves in utero for a radical modification to their respiration at the time of birth, when they move abruptly from an aquatic medium to air?

CNRS researchers, working in collaboration with teams from the Universities of the Méditerranée, Paris-Sud 11 and Paul Cézanne have identified a gene in the mouse that is essential to respiration and consequently to survival at birth. This work, just published in the Journal of Neuroscience, opens the way to better understanding respiratory disorders in humans, which can range from sleep apnea to sudden infant death syndrome.

In mammals, the foetus develops in a liquid environment where the umbilical cord provides a supply of oxygen and pulmonary functions are almost absent. At birth, the newborn moves from intra-uterine aquatic life to independent living in an aerial environment. How does the body prepare itself for such an abrupt transition? We already know that several neuronal circuits intervene in neonatal respiration in mammals. More specifically, two regions situated in the hindbrain have been identified (the pre-Bötzinger complex and the parafacial respiratory group). These neurons are the source of a pacemaker activity, or in other words a rhythm in the brainstem that gives rise to automatic respiratory movements and thus prepares newborns for birth.

The studies performed by researchers in Paris and Marseilles(1) reveal that a protein called TSHZ3 is present in the parafacial respiratory group and plays a major role in the activity of neurons in that region. Newborn mice in which the Tshz3 gene (which codes for the TSHZ3 protein) does not function are unable to breathe at birth and die after a few minutes. Although in principle the pre-Bötzinger complex and parafacial respiratory group have developed correctly in these mutant newborn mice, neurons in the parafacial respiratory group do not display the rhythmic activity that is their specific characteristic. Thus a single gene, Tshz3, is capable of controlling development in the neurons of several elements and cellular events that are essential to breathing at birth.

In the future, collaborative efforts with medical research teams may provide a clearer understanding of the implication of Tshz3 in human respiratory disorders, ranging from sleep apnea to sudden infant death syndrome, which is the principal cause of neonatal deaths in Western countries.


Story Source:

The above story is based on materials provided by CNRS (Délégation Paris Michel-Ange). Note: Materials may be edited for content and length.


Journal Reference:

  1. X. Caubit, M. Thoby-Brisson, N. Voituron, P. Filippi, M. Bévengut, H. Faralli, S. Zanella, G. Fortin, G. Hilaire, and L. Fasano. Teashirt 3 regulates development of neurons involved in both repiratory rhythm and air flow control. Journal of Neuroscience, 14 July 2010

Cite This Page:

CNRS (Délégation Paris Michel-Ange). "Identification of a gene essential to newborn babies' first breath." ScienceDaily. ScienceDaily, 23 July 2010. <www.sciencedaily.com/releases/2010/07/100721085350.htm>.
CNRS (Délégation Paris Michel-Ange). (2010, July 23). Identification of a gene essential to newborn babies' first breath. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/07/100721085350.htm
CNRS (Délégation Paris Michel-Ange). "Identification of a gene essential to newborn babies' first breath." ScienceDaily. www.sciencedaily.com/releases/2010/07/100721085350.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) — A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) — A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) — A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins