Featured Research

from universities, journals, and other organizations

Novel cause for genetic tooth decay

Date:
August 6, 2010
Source:
American Journal of Pathology
Summary:
New research implicates a novel peptide in impaired dentin mineralization in rickets. Rickets, the softening of bones in children, is often caused by vitamin D deficiency due to severe malnutrition. Rickets is one of the most frequent childhood diseases in developing countries and is associated with severe bone deformities, including dental ailments due to impaired dentin mineralization.

Researchers led by Dr. Catherine Chaussain of the University of Paris Descartes implicate a novel peptide in impaired dentin mineralization in rickets. They report their data in the August 2010 issue of the American Journal of Pathology.

Rickets, the softening of bones in children, is often caused by vitamin D deficiency due to severe malnutrition. Rickets is one of the most frequent childhood diseases in developing countries and is associated with severe bone deformities, including dental ailments due to impaired dentin mineralization.

Some cases of rickets, such as familial hypophosphatemic rickets, have a genetic basis. These cases are often caused by a mutation in the protein PHEX. Boukpessi et al hypothesized that PHEX impairment resulted in the release of a peptide, ASARM, which is known to inhibit dentin mineralization. They observed that ASARM was abnormally produced in patients with familial rickets, and that both symptoms and ASARM production could be attenuated by a diet high in vitamin D and phosphate during growth. The presence of the ASARM peptide may thus contribute to impaired dentin mineralization in rickets, in a manner compensated for by vitamin D and phosphate.

Dr. Chaussain and colleagues suggest that "the release of this peptide may partially explain the impaired dentin mineralization associated with the disease in teeth from hypophosphatemic patients with mutation of the PHEX gene. However, treatment during growth may limit the clinical consequences of this anomaly in the dentin of permanent teeth. This observation highlights the importance of improving phosphate and vitamin D environment on dentin mineralization, which compensates the adverse effect of PHEX mutation."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Boukpessi T, Gaucher C, Lιger T, Salmon B, Le Faouder J, Willig C, Rowe PS, Garabιdian M, Meilhac O, Chaussain C. Abnormal presence of the MEPE-derived ASARM peptide in human hypophosphatemic dentin. Am J Pathol, 2010; 177: 803-812

Cite This Page:

American Journal of Pathology. "Novel cause for genetic tooth decay." ScienceDaily. ScienceDaily, 6 August 2010. <www.sciencedaily.com/releases/2010/07/100728120952.htm>.
American Journal of Pathology. (2010, August 6). Novel cause for genetic tooth decay. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2010/07/100728120952.htm
American Journal of Pathology. "Novel cause for genetic tooth decay." ScienceDaily. www.sciencedaily.com/releases/2010/07/100728120952.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) — A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) — A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) — A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins