Featured Research

from universities, journals, and other organizations

Large risk schizophrenia marker revealed

Date:
August 6, 2010
Source:
Cell Press
Summary:
Scientists have identified a genetic variant that substantially increases the risk for developing schizophrenia in Ashkenazi Jewish and other populations. The study associates a deletion on chromosome 3 with increased incidence of schizophrenia.

A group of scientists has identified a genetic variant that substantially increases the risk for developing schizophrenia in Ashkenazi Jewish and other populations. The study, published on August 5th in the American Journal of Human Genetics, associates a deletion on chromosome 3 with increased incidence of schizophrenia.

Related Articles


Schizophrenia is a psychiatric illness that affects ~1% of the world population. Characterized by delusions, hallucinations, and disorganized thinking, it is a devastating disorder.

A group of researchers led by Stephen Warren, Ph.D., from Emory University studied the genetics of schizophrenia by analyzing the prevalence of copy number variants (CNVs) in schizophrenic patients. CNVs are changes in the number of copies of DNA segments throughout the human genome. The researchers began by looking at Ashkenazi Jewish subjects already under study by collaborating scientist Ann E. Pulver, Sc.D. and her team at Johns Hopkins University. The Emory group found an excess of large, rare CNVs in these schizophrenic cases compared to controls.

Combining their analysis with those of previous CNV studies of schizophrenic patients, Warren and his colleagues identify a CNV, specifically, a deletion at 3q29, that associates with schizophrenia with an odds ratio (a measure of effect size) of 16.98. "This odds ratio rivals that of any genome-wide association study of schizophrenia and suggests that the 3q29 deletion confers a significant risk for this severe psychiatric phenotype," explains Warren. An odds ratio of 17 means someone with this deletion is 17 times more likely to develop schizophrenia than someone without the deletion.

This research also highlights candidate genes contained within the deletion that may also be associated with schizophrenia. "Two genes, PAK2 and DLG1, are of particular note as paralogs of these genes are known to be associated with intellectual disability" states Jennifer Mulle, Ph.D., a member of the Emory team. Research is finding that the same or similar variants are associated with related complex disorders and traits. "These exciting results imply the interval at chromosome 3q29 may harbor additional genetic mutations that contribute to schizophrenia susceptibility," continues Dr. Mulle.

If this study is any indication of what lies ahead, a great deal of the missing heritability of complex disorders may be revealed by studying CNVs. "Such rare deletions may be the single most fruitful approach to begin to unravel the mechanism of schizophrenia (and other disorders) as they illuminate genes that provide the substrate for further study," concludes Warren.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jennifer Gladys Mulle, Anne F. Dodd, John A. McGrath, Paula S. Wolyniec, Adele A. Mitchell, Amol C. Shetty, Nara L. Sobreira, David Valle, M. Katharine Rudd, Glen Satten et al. Microdeletions of 3q29 Confer High Risk for Schizophrenia. The American Journal of Human Genetics, August 5, 2010 DOI: 10.1016/j.ajhg.2010.07.013

Cite This Page:

Cell Press. "Large risk schizophrenia marker revealed." ScienceDaily. ScienceDaily, 6 August 2010. <www.sciencedaily.com/releases/2010/08/100805172951.htm>.
Cell Press. (2010, August 6). Large risk schizophrenia marker revealed. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2010/08/100805172951.htm
Cell Press. "Large risk schizophrenia marker revealed." ScienceDaily. www.sciencedaily.com/releases/2010/08/100805172951.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins