Featured Research

from universities, journals, and other organizations

Function of proteins can enhance the progression of viruses and cancer cells

Date:
August 23, 2010
Source:
SUNY Downstate Medical Center
Summary:
In a discovery that has implications for developing treatments against cancer and potentially deadly viruses, researchers have discovered the function of proteins that can enhance the progression of certain viruses and cancer cells.

In a discovery that has implications for developing treatments against cancer and potentially deadly viruses, researchers at SUNY Downstate Medical Center have discovered the function of proteins that can enhance the progression of certain viruses and cancer cells.

Related Articles


Their findings were published in the journal Genes and Development.

According to Tatyana Pestova, PhD, DSc, assistant professor of cell biology, and Christopher Hellen, DPhil, associate professor of cell biology, "The significance of our work is that we have identified proteins (Ligatin, MCT-1 and DENR) that can substitute for the activity of one or more canonical initiation factors in the initiation and ribosome recycling stages of eukaryotic protein synthesis. These factors act either individually (Ligatin) or together (MCT-1 and DENR) to substitute for eIF2 in promoting initiation of translation on a specific subset of mRNAs under conditions when translation is globally repressed. These observations are clinically relevant with respect to (a) viral infections and (b) cancer pathogenesis." Maxim Skabkin, PhD, a research scientist in the Department of Cell Biology, is the lead author of the paper.

The cellular response to counteract viral infection involves activation of pathways that "shut off" translation by phosphorylating eIF2, preventing it from recruiting initiator tRNA to the ribosome. Some viral mRNAs continue to be translated at the same or a reduced rate under these conditions, including those of Hepatitis C virus, human rotaviruses (a major cause of acute, frequently fatal, gastroenteritis in infants), coronaviruses (including SARS), and alphaviruses (e.g. Sindbis virus).

The authors reported a novel eIF2-independent mode of translation initiation in which Ligatin alone or MCT-1 and DENR together promote binding of initiator tRNA to specific ribosomal initiation complexes, and found that this mechanism functions very efficiently for Sindbis virus and to a lesser extent for Hepatitis C virus and related pathogenic viruses. This novel initiation mechanism is thus a potential target for therapeutic inhibition to counteract viral infection.

This eIF2-independent mode of initiation is likely a cellular mechanism that has been co-opted by viruses. MCT-1 (multiple copies in T-cell lymphoma-1) has previously been reported to act at the translational level to increase cell proliferation and survival and to enhance the invasiveness of cancer cells, but how it functions was not known. It is an oncogene that is over-expressed in lung cancer tissues and has been implicated in the development of human T-cell and B-cell lymphomas.

Dr. Hellen adds, "Our identification of a specific role for MCT-1 in promoting eIF2-independent initiation on specific mRNAs could account for its oncogenic activity by promoting the preferential translation of a subset of cancer-related mRNAs into proteins that promote angiogenesis, tumor cell survival, transformation, and metastasis."


Story Source:

The above story is based on materials provided by SUNY Downstate Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maxim A. Skabkin, Olga V. Skabkina, Vidya Dhote, Anton A. Komar, Christopher U.T. Hellen, Tatyana V. Pestova. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. Genes and Development, 2010; DOI: 10.1101/gad.1957510

Cite This Page:

SUNY Downstate Medical Center. "Function of proteins can enhance the progression of viruses and cancer cells." ScienceDaily. ScienceDaily, 23 August 2010. <www.sciencedaily.com/releases/2010/08/100816095758.htm>.
SUNY Downstate Medical Center. (2010, August 23). Function of proteins can enhance the progression of viruses and cancer cells. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2010/08/100816095758.htm
SUNY Downstate Medical Center. "Function of proteins can enhance the progression of viruses and cancer cells." ScienceDaily. www.sciencedaily.com/releases/2010/08/100816095758.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Reuters - Innovations Video Online (Jan. 30, 2015) A nanosensor that mimics the oral effects and sensations of drinking wine has been developed by Danish and Portuguese researchers. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Dog-Loving Astronaut Wins Best Photo of 2015

Dog-Loving Astronaut Wins Best Photo of 2015

Buzz60 (Jan. 30, 2015) Retired astronaut and television host, Leland Melvin, snuck his dogs into the NASA studio so they could be in his official photo. As Mara Montalbano (@maramontalbano) shows us, the secret is out. Video provided by Buzz60
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Rarest Cat on Planet Caught Attacking Monkeys on Camera

Rarest Cat on Planet Caught Attacking Monkeys on Camera

Buzz60 (Jan. 30, 2015) An African Golden Cat, the rarest large cat on the planet was recently caught on camera by scientists trying to study monkeys. The cat comes out of nowhere to attack those monkeys. Patrick Jones (@Patrick_E_Jones) has the rest. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins