Featured Research

from universities, journals, and other organizations

CRP genetic variants crucial in interpreting inflammatory disease activity

Date:
September 21, 2010
Source:
Public Library of Science
Summary:
CRP is commonly used as a serum marker for inflammation or infection, but the genetic effects of CRP variants on acute-phase serum CRP concentrations in patients with rheumatoid arthritis may be large enough to have a clinically relevant impact on the assessment of inflammatory disease activity, which in turn may influence therapeutic decision-making.

CRP is commonly used as a serum marker for inflammation or infection, but the genetic effects of CRP variants on acute-phase serum CRP concentrations in patients with rheumatoid arthritis may be large enough to have a clinically relevant impact on the assessment of inflammatory disease activity, which in turn may influence therapeutic decision making. Furthermore, failure to take into account the potential for genetic effects may result in the inappropriate reassurance or under-treatment of patients simply because they carry low-CRP associated genetic variants.

Related Articles


These are the results of a study by Timothy Vyse from Imperial College London, UK, and colleagues, and published in this week's PLoS Medicine.

The authors studied two independent sets of patients with rheumatoid arthritis (from the UK, and New Zealand and Australia). The authors used a genetic technique (a tagSNP approach) and linear modelling to show that common genetic variants at the CRP locus were associated with acute-phase serum CRP in both patient sets, translating into an approximate 3.5 fold change in expected serum CRP between carriers of two common CRP variants. For example when ESR = 50mm/hr the expected CRP serum level for one common CRP variant was 43.1mg/L and for another CRP variant was 14.2mg/L.

These finding raise questions about the interpretation of acute-phase serum CRP as they suggest that there is a significant association between CRP variants and acute-phase serum CRP concentrations in a group of patients with rheumatoid arthritis. CRP thresholds are used as a diagnostic component of formal clinical algorithms and play an important role in a clinician's decision making process when diagnosing inflammatory disease and making treatment decisions. The authors conclude: "The accuracy and utility of these algorithms might be improved by using a genetically adjusted CRP measurement."

This work was funded by an Arthritis Research UK fellowship awarded to Benjamin Rhodes (grant number 18544). The Health Research Council of New Zealand funded the collection of New Zealand patients.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Aroon Hingorani, Benjamin Rhodes, Marilyn E. Merriman, Andrew Harrison, Michael J. Nissen, Malcolm Smith, Lisa Stamp, Sophia Steer, Tony R. Merriman, Timothy J. Vyse. A Genetic Association Study of Serum Acute-Phase C-Reactive Protein Levels in Rheumatoid Arthritis: Implications for Clinical Interpretation. PLoS Medicine, 2010; 7 (9): e1000341 DOI: 10.1371/journal.pmed.1000341

Cite This Page:

Public Library of Science. "CRP genetic variants crucial in interpreting inflammatory disease activity." ScienceDaily. ScienceDaily, 21 September 2010. <www.sciencedaily.com/releases/2010/09/100921171333.htm>.
Public Library of Science. (2010, September 21). CRP genetic variants crucial in interpreting inflammatory disease activity. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/09/100921171333.htm
Public Library of Science. "CRP genetic variants crucial in interpreting inflammatory disease activity." ScienceDaily. www.sciencedaily.com/releases/2010/09/100921171333.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins