Featured Research

from universities, journals, and other organizations

Deep brain stimulation may help patients with treatment-resistant obsessive-compulsive disorder

Date:
October 6, 2010
Source:
JAMA and Archives Journals
Summary:
Using electrodes to stimulate areas deep within the brain may have therapeutic potential for patients with obsessive compulsive disorder that is refractory to treatment, according to a new report.

Using electrodes to stimulate areas deep within the brain may have therapeutic potential for patients with obsessive compulsive disorder that is refractory to treatment, according to a report in the October issue of Archives of General Psychiatry.

"Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by persistent thoughts (obsessions) and repetitive ritualistic behaviors (compulsions)," the authors write as background information in the article. "It has an estimated lifetime prevalence of 2 percent and affects men and women equally. If left untreated, OCD can destroy a person's capacity to function at work, socially and even at home." Current treatments include cognitive behavioral therapy and medication; these therapies work for only half of patients and reduce symptoms by an average of 40 to 60 percent. An estimated 10 percent of patients remain severely affected by OCD despite receiving the best available treatments.

Damiaan Denys, M.D., Ph.D., of the Academic Medical Center, University of Amsterdam, the Netherlands, and colleagues assessed the safety and effectiveness of deep brain stimulation among a group of 16 patients whose OCD had not responded to previous rounds of treatment. The study consisted of three treatment phases. After having electrodes implanted in the nucleus accumbens, a brain area critical to the reward system, all participants underwent an open phase of eight months during which they received active stimulation and were assessed for symptoms of OCD every two weeks.

After the open phase, patients entered a one-month, double-blind phase in which they were randomly assigned to have the electrodes turned on or off in two-week blocks. Their symptoms were assessed before this phase and after each two-week block. Then, all patients entered a 12-month maintenance phase, during which stimulation was resumed and they were evaluated at three-month intervals.

The researchers ranked obsessive-compulsive symptoms on a scale of zero to 40; patients were classified as responding to treatment if they had a score decrease of at least 35 percent. In the open phase of the study, the average score decreased from 33.7 to 18.0 (46 percent). Among the nine patients classified as responders, scores decreased by an average of 23.7, or 72 percent.

"Anxiety and depressive symptoms decreased by half," the authors write. "The surgical procedure and stimulation were well tolerated. Permanent adverse events were limited to mild forgetfulness and word-finding problems."

During the double-blind phase of the study, in which 14 patients participated, the average difference in score between those receiving active stimulation and those receiving false or "sham" stimulation was 8.3, or 25 percent. The improvements observed in the open phase were sustained over the 12-month maintenance phase.

"In summary, the results of this study indicate that bilateral stimulation of the nucleus accumbens may be an effective and safe treatment in patients with highly refractory OCD and support the therapeutic potential of deep brain stimulation in patients with incapacitating chronic psychiatric disorders," the authors write. "Further research is necessary to optimize this therapy with respect to patient selection and management, target location and investigation of new potential indications."

This study was supported by an unrestricted investigator-initiated research grant by Medtronic Inc., which provided the devices used herein, and by a grant from the Netherlands Organization for Scientific Research ZON-MW VENI program.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Denys, M. Mantione, M. Figee, P. van den Munckhof, F. Koerselman, H. Westenberg, A. Bosch, R. Schuurman. Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder. Archives of General Psychiatry, 2010; 67 (10): 1061 DOI: 10.1001/archgenpsychiatry.2010.122

Cite This Page:

JAMA and Archives Journals. "Deep brain stimulation may help patients with treatment-resistant obsessive-compulsive disorder." ScienceDaily. ScienceDaily, 6 October 2010. <www.sciencedaily.com/releases/2010/10/101004162937.htm>.
JAMA and Archives Journals. (2010, October 6). Deep brain stimulation may help patients with treatment-resistant obsessive-compulsive disorder. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/10/101004162937.htm
JAMA and Archives Journals. "Deep brain stimulation may help patients with treatment-resistant obsessive-compulsive disorder." ScienceDaily. www.sciencedaily.com/releases/2010/10/101004162937.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins