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Carotid stents associated with greater risk of stroke or death than carotid endarterectomy surgery

Date:
October 11, 2010
Source:
JAMA and Archives Journals
Summary:
For patients with blockages in the carotid artery that supplies blood to the brain, carotid artery stenting (a non-surgical treatment) appears to be associated with an increased risk of both short- and long-term adverse outcomes when compared with surgical treatment (carotid endarterectomy), according to a meta-analysis of previously published studies.

For patients with blockages in the carotid artery that supplies blood to the brain, carotid artery stenting (a non-surgical treatment) appears to be associated with an increased risk of both short- and long-term adverse outcomes when compared with surgical treatment (carotid endarterectomy), according to a meta-analysis of previously published studies that was posted online and will appear in the February 2011 print issue of Archives of Neurology, one of the JAMA/Archives journals.

"Carotid artery stenting has emerged as an alternative to carotid endarterectomy for the treatment of carotid artery occlusive disease," the authors write as background information in the article. The therapy -- which involves threading a catheter through the femoral (groin) artery to the carotid artery, inflating an angioplasty balloon to compress plaque and inserting a stent to keep the artery open -- is endorsed by the American Heart Association/American Stroke Association guidelines as a reasonable strategy and recommended by the European Society of Vascular Surgery in certain circumstances. However, its safety and efficacy as compared with carotid endarterectomy (surgery to remove the inner lining of the diseased blood vessel) is controversial.

Sripal Bangalore, M.D., M.H.A., of New York University School of Medicine, New York, and Harvard Clinical Research Institute, Boston, and colleagues conducted a meta-analysis of 13 randomized clinical trials comparing the two treatments conducted through June 2010 and involving 7,477 patients with carotid artery disease. They assessed the risk of death, heart attack (myocardial infarction) and stroke within the periprocedural period (within 30 days of the procedure) as well as intermediate and long-term outcomes.

In the first 30 days, carotid artery stenting was associated with a 65 percent increased risk of death or stroke and a 67 percent increased risk of any stroke. However, the stent procedure was associated with a 55 percent lower risk of heart attack and 85 percent reduction in cranial nerve injury in this timeframe when compared with carotid endarterectomy.

Intermediate- to long-term outcomes were assessed using a composite involving death, any strokes or strokes on the side of the brain with carotid blockage (ipsalateral stroke) within 30 days or thereafter. Carotid artery stenting as compared with carotid endarterectomy was associated with a 19 percent increase in the risk of such an outcome, as well as an increased risk of various combinations of strokes, ipsilateral stroke and death. Stenting was also associated with an 180-percent increase in the risk of restenosis (repeat narrowing of the carotid artery).

"In this largest and most comprehensive meta-analysis to date using outcomes that are standard in contemporary studies, carotid artery stenting was associated with an increased risk of both periprocedural and intermediate to long-term outcomes, but with a reduction in periprocedural myocardial infarction and cranial nerve injury," the authors conclude. "Strategies are urgently needed to identify patients who are best served by carotid artery stenting vs. carotid endarterectomy."

Editorial: Meta-Analysis and Other Data Should Guide Personalized Medical Decisions for Each Patient

"What message can doctors take home from the past surgery vs. stenting horse races, from the numerous reports of results in patients not entered in trials, from the meta-analysis in this month's Archives and from the recently published results of the Carotid Revascularization Endarterectomy vs. Stenting Trial?" write Louis R. Caplan, M.D, of Beth Israel Deaconess Medical Center, Boston, and Thomas G. Brott, M.D., of Mayo Clinic, Jacksonville, Fla., in an accompanying editorial.

"Both therapeutic procedures are effective. Both procedures showed a relatively low rate of serious complications. Surgery is superior concerning some outcomes; stenting seems to have advantages in others," they write. In addition, "aggressive medical treatment of blood lipids, blood pressure and anti-platelets along with lifestyle changes may be as good as or better than either surgery or stenting at stroke and myocardial infarcts prevention."

"The past decades have produced three very effective treatments -- medical, surgical and interventional -- for individuals with carotid artery disease," they conclude. "The results and complications of each can be improved. We have learned much from the trials and they are a beacon to engender even further improvements. However, care of individual patients will always rest in the hands of a trained experienced doctor on one end of a stethoscope and a patient on the other end. Trials can enlighten that encounter but never replace it."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal References:

  1. S. Bangalore, S. Kumar, J. Wetterslev, A. A. Bavry, C. Gluud, D. E. Cutlip, D. L. Bhatt. Carotid Artery Stenting vs Carotid Endarterectomy: Meta-analysis and Diversity-Adjusted Trial Sequential Analysis of Randomized Trials. Archives of Neurology, 2010; DOI: 10.1001/archneurol.2010.262
  2. L. R. Caplan, T. G. Brott. Of Horse Races, Trials, Meta-analyses, and Carotid Artery Stenosis. Archives of Neurology, 2010; DOI: 10.1001/archneurol.2010.268

Cite This Page:

JAMA and Archives Journals. "Carotid stents associated with greater risk of stroke or death than carotid endarterectomy surgery." ScienceDaily. ScienceDaily, 11 October 2010. <www.sciencedaily.com/releases/2010/10/101011173336.htm>.
JAMA and Archives Journals. (2010, October 11). Carotid stents associated with greater risk of stroke or death than carotid endarterectomy surgery. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/10/101011173336.htm
JAMA and Archives Journals. "Carotid stents associated with greater risk of stroke or death than carotid endarterectomy surgery." ScienceDaily. www.sciencedaily.com/releases/2010/10/101011173336.htm (accessed September 23, 2014).

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