Featured Research

from universities, journals, and other organizations

Biomarker shows potential for early diagnosis of lung cancer

Date:
October 15, 2010
Source:
University of North Carolina School of Medicine
Summary:
Researchers have demonstrated that a biomarker called TCF21 may be used to develop a potential screening test for early-stage lung cancer.

A collaboration between physicians and scientists at UNC Lineberger Comprehensive Cancer Center and the University of Texas M.D. Anderson Cancer Center has demonstrated that a biomarker called TCF21 may be used to develop a potential screening test for early-stage lung cancer.

Despite the fact that lung cancer is the leading cause of cancer deaths worldwide, early-stage lung cancer is difficult to diagnose. A number of proposed screening tests, including screening CT scans and serum markers, have not shown any benefit in enhancing patient survival.

TCF21 is a transcription factor -- a protein that binds to DNA, allowing it to reproduce itself accurately, allowing cells to multiply and replace themselves in a consistent manner. When these transcription factors don't work properly (through a process called hypermethylation), cellular growth mechanisms can be disrupted, leading to cancer.

"We were very excited to find evidence of TCF21 hypermethylation in 105 non-small-cell lung cancers of different stages and types, which we then validated by looking at another 300 cases using a tissue microarray," said Kristy Richards, PhD,MD, who led the research.

"More than 80 percent of these cancers show some abnormal expression of this biomarker, meaning that it is a promising target for developing a screening tool. This is important to physicians and patients because surgery and other treatments can be much more effective before the cancer has the opportunity to spread."

The research results were published in the journal Cancer.

Research team members from UNC Lineberger include D. Neil Hayes, MD, MPH. Researchers at M.D. Anderson include corresponding author Ralf Krahe, PhD, Ignacio Wistuba, MD, Guosheng Yin, PhD, Keith Baggerly, PhD, Charmaine Wilson, MD, Lisa Bachinski PhD, Jennifer Churchill, BS, Wenli Dong, PhD, Menghong Sun, PhD, and Baili Zhang, MS.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristy L. Richards, Baili Zhang, Menghong Sun, Wenli Dong, Jennifer Churchill, Linda L. Bachinski, Charmaine D. Wilson, Keith A. Baggerly, Guosheng Yin, D. Neil Hayes, Ignacio I. Wistuba, Ralf Krahe. Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers. Cancer, 2010; DOI: 10.1002/cncr.25472

Cite This Page:

University of North Carolina School of Medicine. "Biomarker shows potential for early diagnosis of lung cancer." ScienceDaily. ScienceDaily, 15 October 2010. <www.sciencedaily.com/releases/2010/10/101014113832.htm>.
University of North Carolina School of Medicine. (2010, October 15). Biomarker shows potential for early diagnosis of lung cancer. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2010/10/101014113832.htm
University of North Carolina School of Medicine. "Biomarker shows potential for early diagnosis of lung cancer." ScienceDaily. www.sciencedaily.com/releases/2010/10/101014113832.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins