Featured Research

from universities, journals, and other organizations

Morphine abuse during adolescence has multigenerational effects on brain

Date:
November 15, 2010
Source:
Society for Neuroscience
Summary:
Abuse of prescription pain relievers, such as morphine, during adolescence alters the brains of future offspring, a new animal study found.

Abuse of prescription pain relievers, such as morphine, during adolescence alters the brains of future offspring, a new animal study found.

Related Articles


The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

"Abuse of prescription pain relievers among adolescents -- girls as well as boys -- is a growing concern," said Elizabeth Byrnes, PhD, of Tufts University. "Unfortunately, the long-term consequences of female adolescent drug use, particularly on future children, are unknown. Our findings suggest that a mother's history of drug use may have a significant impact on her children and grandchildren, even if the woman was not using drugs at the time she got pregnant."

For this study, female rats were given morphine for 10 days during adolescence. The doses were similar to what an abuser of prescription narcotics might use. After a drug-free period, the females were mated with healthy males, and the first and second generation offspring were subsequently studied when they reached adulthood.

First generation male adult offspring demonstrated decreased sensitivity to the drug quinpirole, a chemical that mimics the reward chemical dopamine in the brain. They also found this same effect in the second generation male offspring.

Disruption of dopamine is associated with addiction and psychiatric disorders. "Our model could be used to help determine how substance abuse and other reward-related disorders are passed down through several generations," said Byrnes. "We are currently examining changes in the expression of particular genes in both the mother and her offspring to determine how these effects are transmitted," she said.

Research was supported by the National Institute on Drug Abuse.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Morphine abuse during adolescence has multigenerational effects on brain." ScienceDaily. ScienceDaily, 15 November 2010. <www.sciencedaily.com/releases/2010/11/101115155032.htm>.
Society for Neuroscience. (2010, November 15). Morphine abuse during adolescence has multigenerational effects on brain. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/11/101115155032.htm
Society for Neuroscience. "Morphine abuse during adolescence has multigenerational effects on brain." ScienceDaily. www.sciencedaily.com/releases/2010/11/101115155032.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins