Featured Research

from universities, journals, and other organizations

Regenerative stem cell therapy offers new hope for treating cardiovascular disease

Date:
November 18, 2010
Source:
Northwestern Memorial Hospital
Summary:
Physician researchers are revolutionizing treatment of cardiovascular disease by utilizing patients' own stem cells to regenerate heart and vascular tissue.

Northwestern Medicine physician researchers are revolutionizing treatment of cardiovascular disease by utilizing patients' own stem cells to regenerate heart and vascular tissue. Northwestern Medicine is the lead site for a study examining stem cell transplantation as treatment for critical limb ischemia. Chief investigator Douglas Losordo, MD, director of the Program in Cardiovascular Regenerative Medicine at Northwestern Memorial Hospital and the Eileen M. Foell Professor of Heart Research of Northwestern University's Feinberg School of Medicine, will present the findings of this study at the American Heart Association's Scientific Sessions in Chicago, on November 17.

"Traditionally, cardiovascular medicine has focused on repairing damaged tissues with medication or surgery," said Losordo, also director of the Feinberg Cardiovascular Research Institute. "For some patients, their cardiovascular disease is advanced to the point that standard treatment options are not effective. Regenerative cardiovascular medicine strives to redevelop cardiac and vascular tissue and stimulate new blood supply to areas like the heart and legs by using stem cells already present in the patient's body."

Losordo's limb preservation study examined the effectiveness of stem cell therapy in limb preservation for patients with critical limb ischemia (CLI). CLI develops in patients with severe obstruction of the arteries which limits blood flow to the extremities. CLI results in more than 100,000 amputations annually in the United States. The trial tested the ability of CD34+ cells to stimulate new blood vessel formation in ischemic limbs, which can improve perfusion and salvage function.

The phase II, double-blind placebo controlled trial had a total of 28 patients randomized at 18 U.S. sites. The patients enrolled in this study were Rutherford class 4 and 5, meaning they were in the later stages of peripheral artery disease and at heightened risk for amputation. Patients in the randomized group had CD34 injected at eight locations in the ischemic limb and were followed for 12 months.

"Stem cell treatment was associated with a significant reduction in amputation rate," said Losordo. "Treatment was associated with a 50 percent reduction in the total amputation rate compared to control. Although further study is needed, these results provide evidence that CD34 cell therapy is an effective treatment for critical limb ischemia."

Losordo and his Northwestern Medicine team are leading the field of stem cell therapy for cardiovascular conditions and bringing it to the forefront of medicine. "The results of this study are encouraging and provide evidence for that stem cell therapy can significantly repair cardiac and vascular tissues," said Losordo. "As study of stem cells continues, I believe we're on the verge of a rebirth in the practice of medicine. Using a patient's own cells to regenerate their body has enormous potential to treat conditions that have previously been considered irreversible."


Story Source:

The above story is based on materials provided by Northwestern Memorial Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern Memorial Hospital. "Regenerative stem cell therapy offers new hope for treating cardiovascular disease." ScienceDaily. ScienceDaily, 18 November 2010. <www.sciencedaily.com/releases/2010/11/101117184355.htm>.
Northwestern Memorial Hospital. (2010, November 18). Regenerative stem cell therapy offers new hope for treating cardiovascular disease. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/11/101117184355.htm
Northwestern Memorial Hospital. "Regenerative stem cell therapy offers new hope for treating cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2010/11/101117184355.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Snack Attack: Study Says Action Movies Make You Snack More

Snack Attack: Study Says Action Movies Make You Snack More

Newsy (Sep. 2, 2014) You're more likely to gain weight while watching action flicks than you are watching other types of programming, says a new study published in JAMA. Video provided by Newsy
Powered by NewsLook.com
U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Doctors Fear They're Losing Battle Against Ebola

Doctors Fear They're Losing Battle Against Ebola

AP (Sep. 2, 2014) As a third American missionary is confirmed to have contracted Ebola in Liberia, doctors on the ground in West Africa fear they're losing the battle against the outbreak. (Sept. 2) Video provided by AP
Powered by NewsLook.com
Tech Giants Bet on 3D Headsets for Gaming, Healthcare

Tech Giants Bet on 3D Headsets for Gaming, Healthcare

AFP (Sep. 2, 2014) When Facebook acquired the virtual reality hardware developer Oculus VR in March for $2 billion, CEO Mark Zuckerberg hailed the firm's technology as "a new communication platform." Duration: 02:24 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins