Featured Research

from universities, journals, and other organizations

New insight into neuronal survival after brain injury

Date:
January 12, 2011
Source:
Cell Press
Summary:
A new study identifies a molecule that is a critical regulator of neuron survival after ischemic brain injury. The research may lead to new therapies that reduce damage after a stroke or other injuries that involve an interruption in blood supply to the brain.

A new study identifies a molecule that is a critical regulator of neuron survival after ischemic brain injury. The research, published in the January 13 issue of the journal Neuron, may lead to new therapies that reduce damage after a stroke or other injuries that involve an interruption in blood supply to the brain.

Ischemic brain injury is damage caused by a restriction in blood supply. Neuronal death after an interruption in the supply of oxygen and glucose involves a complex cascade of pathological events and, although previous research has identified key signaling pathways involved in neuronal death, factors contributing to neuronal survival after ischemia are not well understood. "Although a number of molecules and compounds conferring resistance to ischemic stresses have been identified, they have failed to be protective in clinical trials despite promising preclinical data," explains senior study author, Dr. Kazuo Kitagawa from the Osaka University Graduate School of Medicine in Japan.

Earlier research implicated a molecule called cAMP responsive elements binding protein (CREB) in the protection of neurons after ischemia. CREB is known to regulate many different genes and plays a role in diverse physiological processes. In the current study, Dr. Kitagawa, coauthor Dr. Hiroshi Takemori, and their colleagues found that salt-inducible kinase 2 (SIK2) was expressed in neurons at high levels but was reduced after ischemic injury. They went on to show that SIK2 suppressed CREB-mediated gene expression after oxygen and glucose deprivation and that neuronal survival after ischemia was significantly increased in mice that were lacking SIK2.

"We found that oxygen and glucose deprivation induced SIK2 degradation concurrently with regulation of the CREB-specific coactivator transducer of regulated CREB activity 1 (TORC1), resulting in activation of CREB and its downstream targets," says Dr. Takemori. These findings suggest that SIK2 plays a critical role in neuronal survival and may have clinical applications. "Our results suggest that the SIK2-TORC1-CREB signaling pathway may serve as a potential therapeutic target for promoting the survival of neurons," concludes Dr. Kitagawa. "These findings also raise new opportunities for the development of novel therapeutics."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tsutomu Sasaki et al. SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB. Neuron, Volume 69, Issue 1, 13 January 2011, Pages 106-119 DOI: 10.1016/j.neuron.2010.12.004

Cite This Page:

Cell Press. "New insight into neuronal survival after brain injury." ScienceDaily. ScienceDaily, 12 January 2011. <www.sciencedaily.com/releases/2011/01/110112122507.htm>.
Cell Press. (2011, January 12). New insight into neuronal survival after brain injury. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2011/01/110112122507.htm
Cell Press. "New insight into neuronal survival after brain injury." ScienceDaily. www.sciencedaily.com/releases/2011/01/110112122507.htm (accessed April 16, 2014).

Share This



More Mind & Brain News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
App Fights Jet Lag With The Power Of Math

App Fights Jet Lag With The Power Of Math

Newsy (Apr. 13, 2014) Researchers at the University of Michigan have designed an app to fight jet lag by adjusting your body's light intake. Video provided by Newsy
Powered by NewsLook.com
Treatment Gaps Endangering Cops, Mentally Ill

Treatment Gaps Endangering Cops, Mentally Ill

AP (Apr. 10, 2014) As states slash funding for mental health services, police officers are interacting more than ever with people suffering from schizophrenia and other serious disorders of the mind. The consequences can be deadly. (April 10) Video provided by AP
Powered by NewsLook.com
Teen Drinking Rates Linked To Alcohol Mentions In Pop Music

Teen Drinking Rates Linked To Alcohol Mentions In Pop Music

Newsy (Apr. 9, 2014) A University of Pittsburgh study found pop music that mentions alcohol is linked to higher drinking rates among teens. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins