Featured Research

from universities, journals, and other organizations

Researchers describe future target mechanism for antibiotics

Date:
January 17, 2011
Source:
Ume universitet
Summary:
So-called type-3 secretion systems of pathogenic bacteria may be a suitable point of attack for future antibiotics.

So-called type-3 secretion systems of pathogenic bacteria may be a suitable point of attack for future antibiotics. This is shown by Professor Maria Fllman and her associates at Ume University in Sweden in the Proceeding of the National Academy of Sciences, PNAS, in the US.

Related Articles


Many disease-causing bacteria, such as Yersinia, Salmonella, Shigella, and Chlamydia make use of a dedicated protein transport system to transmit pathogenic proteins to host cells. These so-called type-3 secretion systems (T3SS) consist of hollow pin-like structures on the outer shell of the bacteria. Virulence proteins that are exported through this structure are transported into host cells via an unknown mechanism.

The mechanism for this transport has previously been proposed to be occurring by injection via the pin-like structure directly from the inner part of the bacterium into the cytoplasma of the host cell. These researchers at Ume University have now shown that virulence proteins exist on the outside of the bacterium before it has bound to the host cell and that these proteins can be transported into the host cell via a bacteria-associated protein complex. These pioneering findings are a major breakthrough in our understanding of T3SS-dependent bacteria and also open new avenues for developing antibiotics that are more specific to this type of bacteria.

In modern medical research scientists are looking for new methods for delivering proteins into cancer cells. These findings may facilitate the development of such systems by making use of the T3SS protein complex.


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Akopyan, T. Edgren, H. Wang-Edgren, R. Rosqvist, A. Fahlgren, H. Wolf-Watz, M. Fallman. Translocation of surface-localized effectors in type III secretion. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1013888108

Cite This Page:

Ume universitet. "Researchers describe future target mechanism for antibiotics." ScienceDaily. ScienceDaily, 17 January 2011. <www.sciencedaily.com/releases/2011/01/110117082302.htm>.
Ume universitet. (2011, January 17). Researchers describe future target mechanism for antibiotics. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2011/01/110117082302.htm
Ume universitet. "Researchers describe future target mechanism for antibiotics." ScienceDaily. www.sciencedaily.com/releases/2011/01/110117082302.htm (accessed October 24, 2014).

Share This



More Plants & Animals News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins