Featured Research

from universities, journals, and other organizations

Researchers describe future target mechanism for antibiotics

Date:
January 17, 2011
Source:
Ume universitet
Summary:
So-called type-3 secretion systems of pathogenic bacteria may be a suitable point of attack for future antibiotics.

So-called type-3 secretion systems of pathogenic bacteria may be a suitable point of attack for future antibiotics. This is shown by Professor Maria Fllman and her associates at Ume University in Sweden in the Proceeding of the National Academy of Sciences, PNAS, in the US.

Related Articles


Many disease-causing bacteria, such as Yersinia, Salmonella, Shigella, and Chlamydia make use of a dedicated protein transport system to transmit pathogenic proteins to host cells. These so-called type-3 secretion systems (T3SS) consist of hollow pin-like structures on the outer shell of the bacteria. Virulence proteins that are exported through this structure are transported into host cells via an unknown mechanism.

The mechanism for this transport has previously been proposed to be occurring by injection via the pin-like structure directly from the inner part of the bacterium into the cytoplasma of the host cell. These researchers at Ume University have now shown that virulence proteins exist on the outside of the bacterium before it has bound to the host cell and that these proteins can be transported into the host cell via a bacteria-associated protein complex. These pioneering findings are a major breakthrough in our understanding of T3SS-dependent bacteria and also open new avenues for developing antibiotics that are more specific to this type of bacteria.

In modern medical research scientists are looking for new methods for delivering proteins into cancer cells. These findings may facilitate the development of such systems by making use of the T3SS protein complex.


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Akopyan, T. Edgren, H. Wang-Edgren, R. Rosqvist, A. Fahlgren, H. Wolf-Watz, M. Fallman. Translocation of surface-localized effectors in type III secretion. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1013888108

Cite This Page:

Ume universitet. "Researchers describe future target mechanism for antibiotics." ScienceDaily. ScienceDaily, 17 January 2011. <www.sciencedaily.com/releases/2011/01/110117082302.htm>.
Ume universitet. (2011, January 17). Researchers describe future target mechanism for antibiotics. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2011/01/110117082302.htm
Ume universitet. "Researchers describe future target mechanism for antibiotics." ScienceDaily. www.sciencedaily.com/releases/2011/01/110117082302.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Reuters - Innovations Video Online (Jan. 30, 2015) A nanosensor that mimics the oral effects and sensations of drinking wine has been developed by Danish and Portuguese researchers. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Dog-Loving Astronaut Wins Best Photo of 2015

Dog-Loving Astronaut Wins Best Photo of 2015

Buzz60 (Jan. 30, 2015) Retired astronaut and television host, Leland Melvin, snuck his dogs into the NASA studio so they could be in his official photo. As Mara Montalbano (@maramontalbano) shows us, the secret is out. Video provided by Buzz60
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Rarest Cat on Planet Caught Attacking Monkeys on Camera

Rarest Cat on Planet Caught Attacking Monkeys on Camera

Buzz60 (Jan. 30, 2015) An African Golden Cat, the rarest large cat on the planet was recently caught on camera by scientists trying to study monkeys. The cat comes out of nowhere to attack those monkeys. Patrick Jones (@Patrick_E_Jones) has the rest. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins