Mutations in a gene called INF2 are by far the most common cause of a dominantly inherited condition that leads to kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results may help with screening, prevention, and therapy.
Focal segmental glomerulosclerosis (FSGS) attacks the kidney's filtering system and causes serious scarring. Approximately 20,000 persons are currently living with kidney failure due to FSGS in the United States, with an associated annual cost of more than $3 billion. In addition, studies have shown that the incidence of FSGS is increasing. FSGS is a common cause of kidney failure in adults and the second leading cause in children. During the last decade, researchers have identified several genes that are mutated in patients with hereditary FSGS and have gained a better understanding of the mechanisms behind the disease's development. These advances are useful for genetic counseling and for developing strategies aimed at prevention and treatment.
One of the genes mutated in patients with hereditary, autosomal dominant FSGS is the INF2 gene, initially discovered by Elizabeth J. Brown and Martin R. Pollak (Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Renal Division, Children's Hospital, Boston, Massachusetts, USA. Nat Genet. 2010 Jan;42(1):72-6. Epub 2009 Dec 20. Erratum in: Nat Genet. 2010 Apr;42(4):361. Tonna, Stephen J.), which produces a protein that helps maintain the structure of specialized kidney cells called podocytes. Corinne Antignac MD, PhD, Olivia Boyer, MD (Hôpital Necker-Enfants Malades and Université Paris Descartes, in Paris, France) and their colleagues conducted a study to confirm INF2's importance in the development of FSGS and to better determine the prevalence of INF2 mutations in a worldwide group of pediatric and adult patients.
The investigators screened 54 families (78 patients) with a history of autosomal dominant FSGS and detected mutations in the INF2 gene in 17% of them. The mutations were located in one particular region of the gene that corresponds to a part of the INF2 protein that interacts with podocyte proteins. This information might shed light on the mechanism behind INF2's involvement in the development of FSGS and could be helpful as researchers design drugs to prevent or treat the disease. One of these mutations appeared in only one of 84 patients with sporadic (nonhereditary) FSGS.
"INF2 is a major gene of autosomal dominant FSGS. Screening for INF2 mutations needs to be strongly considered in patients with an autosomal dominant familial history of FSGS," the authors concluded.
Study co-authors include Geneviève Benoit, MD, Olivier Gribouval, Fabien Nevo, Marie-Josèphe Tête, MD, Jean-Pierre Grunfeld, MD, Christophe Legendre, MD, Dominique Joly, MD, PhD, Marie-Claire Gubler, MD, Géraldine Mollet, PhD (Hôpital Necker-Enfants Malades); Jacques Dantal, MD, PhD (CHU Hôtel Dieu, in Nantes, France); Brigitte Gilbert-Dussardier, MD (CHU La Milétrie, in Poitiers, France); Guy Touchard, MD (Hopital Jean Bernard, in Poitiers, France); Alexandre Karras, MD (Hôpital Européen Georges Pompidou, in Paris, France); Claire Presne, MD (CHU d'Amiens, in Amiens, France); Philippe Rieu, MD (Hôpital du Kremlin-Bicêtre, France); Nabil Mohsin, MD (Royal Hospital, in Muscat, Oman); Isabelle Broutin, PhD (CNRS, in Paris, France); Thierry Hannedouche, MD, PhD (Hôpitaux Universitaires de Strasbourg, France); and Valérie Moal, MD (Hôpital de la Conception, in Marseille, France).
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