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A diagnostic marker in hepatocellular carcinoma

Date:
January 31, 2011
Source:
World Journal of Gastroenterology
Summary:
A research team from South Korea investigated the expression profile of E2F5 in primary hepatocellular carcinomas (HCCs) and explored the biological implications of E2F5 overexpression. They found that E2F5 is commonly overexpressed in primary HCC and that E2F5 knockdown significantly repressed the growth of HCC cells.

E2F5 is a member of the E2F transcription factor family, and plays a key role in cell growth and proliferation. Overexpression of E2F5 has been reported in various human cancers, but not in liver cancer, and its biological implication is largely unknown.

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It is not known whether E2F5 plays a tumor suppressor role or an oncogenic role. Furthermore, there has been no report on the expression profile of E2F5 in HCC and its biological implications on hepatocarcinogenesis.

A research article published on January 28, 2011 in the World Journal of Gastroenterology addresses this question. In this study, the authors investigated the expression profile of E2F5 in primary HCCs and explored the biological effects of E2F5 overexpression by knockdown of the gene.

This is the first evidence that E2F5 is commonly overexpressed in primary human HCC and that E2F5 knockdown profoundly repressed the growth of HCC cells. The overexpression of E2F5 may induce uncontrollable cell cycle progression in liver cells and eventually contribute to cancer transformation by working together with other carcinogenic factors. This study will help to understand hepatocarcinogenesis mechanisms and to define therapeutic targets of early HCC.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jiang Y, Yim SH, Xu HD, Jung SH, Yang SY, Hu HJ, Jung CK, Chung YJ. A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. World Journal of Gastroenterology, 2011; 17 (4): 470 DOI: 10.3748/wjg.v17.i4.470

Cite This Page:

World Journal of Gastroenterology. "A diagnostic marker in hepatocellular carcinoma." ScienceDaily. ScienceDaily, 31 January 2011. <www.sciencedaily.com/releases/2011/01/110131133231.htm>.
World Journal of Gastroenterology. (2011, January 31). A diagnostic marker in hepatocellular carcinoma. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2011/01/110131133231.htm
World Journal of Gastroenterology. "A diagnostic marker in hepatocellular carcinoma." ScienceDaily. www.sciencedaily.com/releases/2011/01/110131133231.htm (accessed November 23, 2014).

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