Featured Research

from universities, journals, and other organizations

Mapping proteins on chromosome 19

Date:
February 3, 2011
Source:
Lund University
Summary:
Today, we know what all the genes on a person's 46 chromosomes look like, but it is only by studying the gene coding information linked to different proteins that we can gain knowledge that can lead to new drug developments. Researchers at one university have now taken on responsibility for coordinating the mapping of all the proteins of chromosome 19.

Today, we know what all the genes on a person's 46 chromosomes look like, but it is only by studying the gene coding information linked to different proteins that we can gain knowledge that can lead to new drug developments. Researchers at Lund University in Sweden have taken on responsibility for coordinating the mapping of all the proteins of chromosome 19.

The genes that make up the human genome were mapped by HUGO, the Human Genome Organisation, and published in 2001. Now the project is expanding into the HUPO, the Human Proteome Organisation. Within the framework of this organisation, many hundreds of researchers around the world will work together to identify the proteins that the different genes give rise to in the human body.

"The 'proteome', the set of all human proteins, is significantly more complicated than the genome. There are over 20 000 proteins coded by the genome in the human body and each protein can have a wide variety of forms, depending on where it is processed and localised and its function," says György Marko-Varga, clinical protein science leader at the Department of Measurement Technology and Industrial Electrical Engineering.

Last autumn, the protein researchers within HUPO decided to divide themselves into international networks and take on one chromosome each. The journal Nature has dubbed the initiative "Adopt-a-chromosome," and each network was able to 'claim' a chromosome in which they were particularly interested. Chromosome 19 was the obvious choice for the Lund researchers.

"Together with Professor Thomas Laurell, I have conducted research on the possibility of detecting the presence of prostate cancer using developments in microchip technology. We know that a number of proteins associated with prostate cancer are controlled by chromosome 19. Logically, it was an easy decision for us at Lund University to take on chromosome 19," says György Marko-Varga.

He is now the coordinator of a large network that had its first meeting at the Pufendorf Institute in Lund on 26 January. Researchers attended from Sweden, Norway, India, Germany, China and Spain.

Sequencing all the proteins linked to chromosome 19 is just the first step in the process. The next stage will be to develop methods to extract these specific proteins from, for example, a blood sample from a cancer patient. In the third stage, these methods will be used to see if any of the proteins from chromosome 19 are linked and correlated to prostate, brain or lung cancer, diabetes or cardiovascular disease. This will involve studying samples from biobanks (collections of tissue and blood samples) related to these diseases.

"Modern development of new drugs is almost entirely directed towards the target proteins that play a key role in a given disease. If you see that patients with a certain disease have abnormally high or low levels of a certain protein in their bodies then you can move on to see how this target protein is associated with the development of the disease. It may be possible to stop the disease by regulating the effect of the protein in question," says György Marko-Varga. "A good example is EGFR regulation in lung cancer, where I have been involved in probably the largest diagnostic study ever conducted, with thousands of patients, evaluating a personalised medicine drug in Asia."

The results of the work carried out in the network will be loaded into a publicly available database that can be used by both industrial and academic researchers worldwide.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Cite This Page:

Lund University. "Mapping proteins on chromosome 19." ScienceDaily. ScienceDaily, 3 February 2011. <www.sciencedaily.com/releases/2011/02/110203081453.htm>.
Lund University. (2011, February 3). Mapping proteins on chromosome 19. ScienceDaily. Retrieved August 26, 2014 from www.sciencedaily.com/releases/2011/02/110203081453.htm
Lund University. "Mapping proteins on chromosome 19." ScienceDaily. www.sciencedaily.com/releases/2011/02/110203081453.htm (accessed August 26, 2014).

Share This




More Health & Medicine News

Tuesday, August 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) — The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) — A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) — A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) — A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins