Antibody-directed chemotherapy offers improved survival to particular sub-groups of leukemia sufferers, a Cardiff University-led study has found.
The findings suggest that the treatment may be effective for the majority of younger acute myeloid leukemia (AML) sufferers, who can be identified by genetic profiling.
The research team studied more than a thousand patients, predominantly under 60, who received a combination of chemotherapy and the drug Gemtuzumab Ozogamicin (commercial name Mylotarg).
The study found no overall difference in survival rates across the whole study group. However, once the patients were broken down by pre-determined sub-groups, the researchers found significant differences.
For patients whose chromosomes showed they were already at low risk, the team found that combined treatment delivered a marked survival advantage. There was no advantage for those at high risk, and a trend towards a benefit for those at intermediate risk. Around 70 per cent of patients were found to have a predicted improvement of 10 per cent of surviving for five years. A sub-group with Core Binding Factor (CBF) leukemia was found to have a particularly clear benefit from the treatment.
Professor Alan Burnett of Cardiff University's School of Medicine, who led the study, said: "We already know that Acute Myeloid Leukemia is a collection of diseases. Our study suggests that particular treatments may need to be targeted to these particular sub-groups. We have found that CBF patients have distinctly better survival chances, with few additional side-effects, if Mylotarg is combined with conventional chemotherapy. Further research is required into this prospect."
The research was supported by a grant from the Medical Research Council and conducted at hospitals across the UK and in Denmark. The findings have just been published in the Journal of Clinical Oncology and are also the subject of an editorial in the journal.
- A. K. Burnett, R. K. Hills, D. Milligan, L. Kjeldsen, J. Kell, N. H. Russell, J. A. L. Yin, A. Hunter, A. H. Goldstone, K. Wheatley. Identification of Patients With Acute Myeloblastic Leukemia Who Benefit From the Addition of Gemtuzumab Ozogamicin: Results of the MRC AML15 Trial. Journal of Clinical Oncology, 2010; 29 (4): 369 DOI: 10.1200/JCO.2010.31.4310
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