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Rare HIV-positive individuals shed light on how body could effectively handle infection

Date:
February 24, 2011
Source:
Public Library of Science
Summary:
Although untreated HIV infection eventually results in immunodeficiency (AIDS), a small group of people infected with the virus, called elite suppressors (0.5 percent of all HIV-infected individuals), are naturally able to control infection in the absence of antiretroviral therapy, or HAART. Elite suppressors and HIV- infected individuals treated with HAART have similar levels of virus in the blood stream.

Although untreated HIV infection eventually results in immunodeficiency (AIDS), a small group of people infected with the virus, called elite suppressors (0.5 percent of all HIV-infected individuals), are naturally able to control infection in the absence of antiretroviral therapy, or HAART.

Elite suppressors and HIV- infected individuals treated with HAART have similar levels of virus in the blood stream. However, levels of HIV integrated into immune cells are much lower in elite suppressors compared to levels in cells from HIV-infected individuals on HAART, according to a study by University of Pennsylvania School of Medicine researchers published in PLoS Pathogens.

Elite suppressors are thought to have a more effective immune response to HIV; specifically, more effective killer T cells, the subgroup of white blood cells that kill cells infected with viruses. HIV is an RNA virus that converts its RNA genome into DNA intermediates in order to replicate.

One important step in the HIV life cycle is integration -- where HIV DNA inserts into the chromosomes of human helper T cells. Cells that contain the integrated form of HIV DNA and are metabolically less active appear to be resistant to antiretroviral therapy and persist in the host, forming a latent reservoir. It will be important to understand why the HIV reservoir is lower in elite suppressors than in HIV infected individuals on HAART. To begin to address this question, it would be interesting to see if the level of integration would be lower still after placing elite suppressors on HAART. The investigators speculate that therapeutic vaccinations aimed at generating killer T cells similar to those in elite suppressors may be effective against the treatment resistant latent reservoir.

The cohort of elite suppressors was characterized by NIH researchers who also contributed to the study.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Erin H. Graf, Angela M. Mexas, Jianqing J. Yu, Farida Shaheen, Megan K. Liszewski, Michele Di Mascio, Stephen A. Migueles, Mark Connors, Una O'Doherty. Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV Patients On and Off HAART. PLoS Pathogens, 2011; 7 (2): e1001300 DOI: 10.1371/journal.ppat.1001300

Cite This Page:

Public Library of Science. "Rare HIV-positive individuals shed light on how body could effectively handle infection." ScienceDaily. ScienceDaily, 24 February 2011. <www.sciencedaily.com/releases/2011/02/110224201857.htm>.
Public Library of Science. (2011, February 24). Rare HIV-positive individuals shed light on how body could effectively handle infection. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/02/110224201857.htm
Public Library of Science. "Rare HIV-positive individuals shed light on how body could effectively handle infection." ScienceDaily. www.sciencedaily.com/releases/2011/02/110224201857.htm (accessed April 20, 2014).

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