Featured Research

from universities, journals, and other organizations

Compound from Chinese medicine blocks biofilm formation on medical implant materials

Date:
March 22, 2011
Source:
American Society for Microbiology
Summary:
A compound that is an active ingredient in plants commonly used in Chinese medicine prevents biofilm formation on polystyrene and polycarbonate surfaces by Staphylococcus aureus. The research suggests that this compound, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose (PGG) is highly promising for clinical use in preventing biofilm formation by S. aureus.

A compound that is an active ingredient in plants commonly used in Chinese medicine prevents biofilm formation on polystyrene and polycarbonate surfaces by Staphylococcus aureus. The research suggests that this compound, 1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose (PGG) is highly promising for clinical use in preventing biofilm formation by S. aureus. The paper is published in the March 2011 issue of the journal Antimicrobial Agents and Chemotherapy.

S. aureus commonly forms biofilms on medical implants, causing pneumonia, meningitis, endocarditis, osteomyelitis, and bloodstream and urinary tract infections. Biofilms, which are far tougher than bacteria not incorporated into biofilms, are resistant to antibiotics even when the individual bacteria composing the biofilm lack antibiotic resistance genes. Once biofilms become attached to the surfaces of medical devices, they are extremely difficult to expunge.

PGG is "far more potent" than several other compounds found to inhibit biofilms, including IDA, NAC, and NPM, according to the report. Despite that potency, PGG did not kill S. aureus. It is also non-toxic to human epithelial and fibroblast cells. PGG likely inhibits biofilm formation during the initial attachment stage, as the investigators found PGG to be effective only when it is added to a medium within an hour after seeding. Besides polystyrene and polycarbonates, PGG inhibited biofilm formation on silicon rubber, a material commonly used in catheters, and on glass coverslips.

PGG is an active ingredient in plants that are commonly used in Chinese medicine to treat inflammation. It was one of 48 compounds purified form medicinal plants that the researchers screened for efficacy in inhibiting S. aureus biofilm formation. PGG was on sole compound from among them that did not kill the pathogens.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. M.-H. Lin, F.-R. Chang, M.-Y. Hua, Y.-C. Wu, S.-T. Liu. Inhibitory Effects of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucopyranose on Biofilm Formation by Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 2010; 55 (3): 1021 DOI: 10.1128/AAC.00843-10

Cite This Page:

American Society for Microbiology. "Compound from Chinese medicine blocks biofilm formation on medical implant materials." ScienceDaily. ScienceDaily, 22 March 2011. <www.sciencedaily.com/releases/2011/03/110321203304.htm>.
American Society for Microbiology. (2011, March 22). Compound from Chinese medicine blocks biofilm formation on medical implant materials. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/03/110321203304.htm
American Society for Microbiology. "Compound from Chinese medicine blocks biofilm formation on medical implant materials." ScienceDaily. www.sciencedaily.com/releases/2011/03/110321203304.htm (accessed July 31, 2014).

Share This




More Plants & Animals News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com
Florida Panther Rebound Upsets Ranchers

Florida Panther Rebound Upsets Ranchers

AP (July 31, 2014) With Florida's panther population rebounding, some ranchers complain the protected predators are once again killing their calves. (July 31) Video provided by AP
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Raw: Thousands Flocking to German Crop Circle

Raw: Thousands Flocking to German Crop Circle

AP (July 30, 2014) Thousands of people are trekking to a Bavarian farmer's field to check out a mysterious set of crop circles. (July 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins