Featured Research

from universities, journals, and other organizations

Gene responsible for severe skin condition identified in research on epilepsy drug side-effect

Date:
March 24, 2011
Source:
University of Liverpool
Summary:
Scientists have identified a gene that could indicate if epilepsy patients starting drug treatment are likely to experience side-effects resulting in blistering of the skin.

Scientists at the University of Liverpool and the Royal College of Surgeons in Ireland have identified a gene that could indicate if epilepsy patients starting drug treatment are likely to experience side-effects resulting in blistering of the skin.

Related Articles


The drug, called carbamazepine, is commonly used to treat patients with epilepsy and other diseases such as depression and trigeminal neuralgia. Although successful in treating the majority of patients, carbamazepine can cause side-effects that range from a mild skin irritation to severe blistering of the whole body.

The team, in collaboration with the Wellcome Trust Sanger Institute, screened more than a million variants in DNA across the human genome to understand why some patients are more prone to the drug's side-effects than others. Research in Taiwan has already identified a gene that predisposes Asian patients to the skin condition, but Liverpool scientists discovered that this gene could not be used to predict the reaction in Caucasian people.

Researchers have now identified a gene, called HLA-A*3101, in Caucasian patients that increases the risk of developing a reaction to the drug from 5% to 26%. Researchers are now working with clinicians and drug regulators to investigate how these new findings can translate into clinical practice.

Professor Munir Pirmohamed, NHS Chair in Pharmacogenetics from the University's Wolfson Centre for Personalised Medicines, said: "Adverse drug reactions are a major cause of hospital admissions. Carbamazepine is widely used and the majority of patients respond well to the treatment, but a small percentage develop skin conditions that in severe circumstances can result in painful blistering all over the body.

"For the first time we have found a significant link between the drug and the skin condition in Caucasian people that also complements the findings in Asian patients. We can now begin to work with clinicians and regulators to maximise the benefits of the drug and minimise the side-effects."

Dr Ana Alfirevic, from the University's Wolfson Centre for Personalised Medicine, said: "This is a significant finding that highlights the importance and advancement of new genetic technologies. We aim to support the development of medicines based on a patient's unique genetic make-up to allow clinicians to prescribe the most effective and safe treatments."

Dr Gianpiero Cavalleri, from the Royal College of Surgeons, said: "Rapid advances in genetic technology, together with a strong collaborative effort, have allowed us to make this important advance, which should make the treatment of epilepsy safer. Working with colleagues in Europe and the US, we have been able to access large numbers of patients to allow us to investigate common genetic trends and the mechanisms that result in this potentially serious condition."

Research conducted at the University was funded by the Department of Health and is published in the New England Journal of Medicine.

Other collaborators in the research include Imperial College London; University College London; Harvard University; and Duke University.

Other funders of the research include the National Institute for Health Research (NIHR); the Wellcome Trust; the Wolfson Foundation; and the Medical Research Council (MRC) Centre for Drug Safety Science.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Journal Reference:

  1. Pei Chen, Juei-Jueng Lin, Chin-Song Lu, Cheung-Ter Ong, Peiyuan F. Hsieh, Chih-Chao Yang, Chih-Ta Tai, Shey-Lin Wu, Cheng-Hsien Lu, Yung-Chu Hsu, Hsiang-Yu Yu, Long-Sun Ro, Chung-Ta Lu, Chun-Che Chu, Jing-Jane Tsai, Yu-Hsiang Su, Sheng-Hsing Lan, Sheng-Feng Sung, Shu-Yi Lin, Hui-Ping Chuang, Li-Chen Huang, Ying-Ju Chen, Pei-Joung Tsai, Hung-Ting Liao, Yu-Hsuan Lin, Chien-Hsiun Chen, Wen-Hung Chung, Shuen-Iu Hung, Jer-Yuarn Wu, Chi-Feng Chang, Luke Chen, Yuan-Tsong Chen, Chen-Yang Shen. Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan. New England Journal of Medicine, 2011; 364 (12): 1126 DOI: 10.1056/NEJMoa1009717

Cite This Page:

University of Liverpool. "Gene responsible for severe skin condition identified in research on epilepsy drug side-effect." ScienceDaily. ScienceDaily, 24 March 2011. <www.sciencedaily.com/releases/2011/03/110323183812.htm>.
University of Liverpool. (2011, March 24). Gene responsible for severe skin condition identified in research on epilepsy drug side-effect. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/03/110323183812.htm
University of Liverpool. "Gene responsible for severe skin condition identified in research on epilepsy drug side-effect." ScienceDaily. www.sciencedaily.com/releases/2011/03/110323183812.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins