Featured Research

from universities, journals, and other organizations

New therapeutic target for lung cancer

Date:
May 12, 2011
Source:
Public Library of Science
Summary:
A new therapeutic target for lung cancer has been discovered. It was found that a variant of the protein AIMP2 is highly expressed in lung cancer cells and also that patients demonstrating high expression of this variant show lower survival.

A new therapeutic target for lung cancer has been discovered by researchers at Seoul National University. It was found that a variant of the protein AIMP2 is highly expressed in lung cancer cells and also that patients demonstrating high expression of this variant show lower survival.

Related Articles


The study is published on March 31 in the open-access journal PLoS Genetics.

Lung cancer is one of the world's most common cancers and a leading cause of death resulting from cancer. Despite treatment with a combination of surgery, radiation and drugs, the survival rate for patients has not drastically improved over the past few decades. It had previously been shown that the protein AIMP2 acted as a tumor-suppressor by interacting with another oncosuppressor, p53. However, whether AIMP2 was indeed pathologically linked to human cancer had not been definitively proved. This investigation discovered that a variant of AIMP2 is highly expressed in human lung cancer cells. AIMP2-DX2 compromises the tumor-suppressing activity of AIMP2 by competitively binding to p53. It was also shown that suppression of AIMP2-DX2 slowed tumor growth, suggesting that this could be an exciting new therapeutic target.

New innovative therapies are important not only because of the high mortality rate associated with lung cancer, but because the majority of the drugs are cytotoxic, causing many adverse effects. These findings could create an opportunity to develop new innovative cancer drugs, as well as presenting a new target that could also be applied to other cancers.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jin Woo Choi, Dae Gyu Kim, Al-Eum Lee, Hye Rim Kim, Jin Young Lee, Nam Hoon Kwon, Young Kee Shin, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, Yoon-La Choi, Jhingook Kim, Seung Hyun Oh, Bora Kim, Soo-Youl Kim, Hyo-Sung Jeon, Jae Yong Park, Hyunseok Peter Kang, Bum Joon Park, Jung Min Han, Sunghoon Kim. Cancer-Associated Splicing Variant of Tumor Suppressor AIMP2/p38: Pathological Implication in Tumorigenesis. PLoS Genetics, 2011; 7 (3): e1001351 DOI: 10.1371/journal.pgen.1001351

Cite This Page:

Public Library of Science. "New therapeutic target for lung cancer." ScienceDaily. ScienceDaily, 12 May 2011. <www.sciencedaily.com/releases/2011/03/110331191518.htm>.
Public Library of Science. (2011, May 12). New therapeutic target for lung cancer. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2011/03/110331191518.htm
Public Library of Science. "New therapeutic target for lung cancer." ScienceDaily. www.sciencedaily.com/releases/2011/03/110331191518.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins