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Long-term use of antibiotic to treat acne not associated with increased bacterial resistance, study finds

Date:
May 26, 2011
Source:
JAMA and Archives Journals
Summary:
The prolonged use of tetracycline antibiotics commonly used to treat acne was associated with a reduced prevalence of Staphylococcus aureus bacteria and was not associated with increased resistance to the tetracycline antibiotics, according to a new study.

The prolonged use of tetracycline antibiotics commonly used to treat acne was associated with a reduced prevalence of Staphylococcus aureus bacteria and was not associated with increased resistance to the tetracycline antibiotics, according to a report posted online that will appear in the August print issue of Archives of Dermatology, one of the JAMA/Archives journals.

Staphylococcus aureus is found in both hospital and community settings. "While S aureus colonizes the skin, it can also be responsible for localized cutaneous infections and life-threatening systemic infections," the authors write as background information in the article. "At one time, it was sensitive to many antibiotics and antimicrobial agents. However, because of its ability to adapt to these therapies and become resistant, clinical scenarios now exist in which few therapeutic options remain to treat this organism. Therefore, methicillin-resistant S aureus (MRSA) has become commonplace."

Matthew Fanelli, M.D., and colleagues at the University of Pennsylvania School of Medicine, Philadelphia, conducted a survey study of patients treated for acne to determine the frequency of S aureus colonization and to compare the susceptibility patterns between patients who are using antibiotics and those who are not using antibiotics. A total of 36 of the 83 patients in the study (43 percent) were colonized with S aureus. Two of the 36 patients (6 percent) had MRSA; 20 (56 percent) had S aureus solely in their throats; nine (25 percent) had S aureus solely in their noses; and seven (19 percent) had S aureus in both their noses and throats.

"Long-term use of antibiotics decreased the prevalence of S aureus colonization by nearly 70 percent," the authors report. "A decreased rate of colonization was noted with the use of both oral and topical antibiotics."

"Fewer than 10 percent of the isolates of S aureus were resistant to tetracyclines, the most commonly used antibiotic family to treat acne," they write. "Resistance to erythromycin and clindamycin was mostly prevalent among our isolates and was noted in the patients who did and did not use antibiotics."

The study results contradict current dogma about long-term use of antibiotics.

"Specifically, in our study, the prolonged use of antibiotics from the tetracycline class that are commonly used to treat acne lowered the prevalence of colonization by S aureus and did not increase resistance to the tetracycline antibiotics," the authors conclude. "Future research should be conducted with respect to other organisms and antibiotics."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matthew Fanelli; Eli Kupperman; Ebbing Lautenbach; Paul H. Edelstein; David J. Margolis. Antibiotics, Acne, and Staphylococcus aureus Colonization. Archives of Dermatology, 2011; DOI: 10.1001/archdermatol.2011.67

Cite This Page:

JAMA and Archives Journals. "Long-term use of antibiotic to treat acne not associated with increased bacterial resistance, study finds." ScienceDaily. ScienceDaily, 26 May 2011. <www.sciencedaily.com/releases/2011/04/110411163811.htm>.
JAMA and Archives Journals. (2011, May 26). Long-term use of antibiotic to treat acne not associated with increased bacterial resistance, study finds. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/04/110411163811.htm
JAMA and Archives Journals. "Long-term use of antibiotic to treat acne not associated with increased bacterial resistance, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411163811.htm (accessed September 23, 2014).

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