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Probiotic may reduce rate of recurrent urinary tract infections in women, study suggests

Date:
April 18, 2011
Source:
Infectious Diseases Society of America
Summary:
Urinary tract infections are common in women and occur frequently, affecting 2 to 3 percent of all women. A depletion of vaginal lactobacilli, a type of bacteria, is associated with urinary tract infection risk, which suggests that replenishing these bacteria may be beneficial. Researchers conducted a double-blind placebo-controlled trial to investigate this theory. Their results suggest that a probiotic may reduce the rate of recurrent urinary tract infections in women prone to these infections.

Urinary tract infections are common in women, costing an estimated $2.5 billion per year to treat in 2000 in the United States alone. These infections frequently recur, affecting 2 to 3 percent of all women. A depletion of vaginal lactobacilli, a type of bacteria, is associated with urinary tract infection risk, which suggests that replenishing these bacteria may be beneficial.

Researchers conducted a double-blind placebo-controlled trial to investigate this theory. Their results are published in Clinical Infectious Diseases.

In the study, young women with a history of recurrent urinary tract infections received antibiotics for acute urinary tract infections. They were then randomized to receive either a Lactobacillus crispatus intravaginal suppository probiotic, called LACTIN-V, or a placebo for five days, then once a week for 10 weeks.

The results suggest that the probiotic may reduce the rate of recurrent urinary tract infections in women prone to these infections. Of the 100 women who participated in the study, 50 received LACTIN-V, and 50 received the placebo. Seven of the women who received LACTIN-V had at least one urinary tract infection, compared to 13 in the placebo group.

According to study author Ann Stapleton, MD, of the University of Washington in Seattle, "Larger efficacy trials of this novel preventive method for recurrent urinary tract infections are warranted to determine if use of vaginal Lactobacillus could replace long-term antimicrobial preventive treatments."


Story Source:

The above story is based on materials provided by Infectious Diseases Society of America. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. E. Stapleton, M. Au-Yeung, T. M. Hooton, D. N. Fredricks, P. L. Roberts, C. A. Czaja, Y. Yarova-Yarovaya, T. Fiedler, M. Cox, W. E. Stamm. Randomized, Placebo-controlled Phase 2 Trial of a Lactobacillus crispatus Probiotic Given Intravaginally for Prevention of Recurrent Urinary Tract Infection. Clinical Infectious Diseases, 2011; DOI: 10.1093/cid/cir183

Cite This Page:

Infectious Diseases Society of America. "Probiotic may reduce rate of recurrent urinary tract infections in women, study suggests." ScienceDaily. ScienceDaily, 18 April 2011. <www.sciencedaily.com/releases/2011/04/110415083151.htm>.
Infectious Diseases Society of America. (2011, April 18). Probiotic may reduce rate of recurrent urinary tract infections in women, study suggests. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/04/110415083151.htm
Infectious Diseases Society of America. "Probiotic may reduce rate of recurrent urinary tract infections in women, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/04/110415083151.htm (accessed April 18, 2014).

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