Featured Research

from universities, journals, and other organizations

Adalimumab levels detected in cord blood and infants exposed in utero, researchers report

Date:
May 8, 2011
Source:
Digestive Disease Week
Summary:
Adalimumab, a drug often prescribed for women with Crohn's disease, actively crosses the placenta during the final trimester of pregnancy and remains in a newborn's bloodstream for at least three months, researchers have found.

Adalimumab (ADA), a drug often prescribed for women with Crohn's disease, actively crosses the placenta during the final trimester of pregnancy and remains in a newborn's bloodstream for at least three months, researchers at the University of California San Francisco have found.

The new study has implications for pregnant women and their obstetricians and pediatricians because ADA is known to decrease the immune system's ability to fight infection. Infants exposed in utero should be monitored closely for infection in the first six months of life and should not receive any live-virus vaccines during that time, cautioned lead researcher Uma Mahadevan, MD, who presented the latest findings at Digestive Disease Week® 2011, being held in Chicago.

"Since there is some placental transfer of adalimumab before birth, you have to be vigilant in the first six months of life for the baby," said Dr. Mahadevan, an associate professor of medicine. "However, our findings do not suggest that a pregnant woman should discontinue the drug. Stopping it actually can be more harmful to both baby and mother because of the risk of miscarriage, preterm birth and low birth weight if the Crohn's disease flares."

The study followed five pregnant women with Crohn's disease who were taking ADA. On the day of delivery, ADA levels were measured in the mother, newborn and cord blood. In all cases, the cord blood showed higher levels than the maternal levels -- indicating transfer from the mother -- and significant ADA levels were found in three of the newborn samples. Levels continued to be checked in the infants until ADA could no longer be identified.

"At a minimum, it can be detected to three months from birth," Dr. Mahadevan noted.

Dr. Mahadevan said future studies should explore the effects of medications during children's initial years as well as potential risks later in life because of their exposure in utero.


Story Source:

The above story is based on materials provided by Digestive Disease Week. Note: Materials may be edited for content and length.


Cite This Page:

Digestive Disease Week. "Adalimumab levels detected in cord blood and infants exposed in utero, researchers report." ScienceDaily. ScienceDaily, 8 May 2011. <www.sciencedaily.com/releases/2011/05/110508134939.htm>.
Digestive Disease Week. (2011, May 8). Adalimumab levels detected in cord blood and infants exposed in utero, researchers report. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/05/110508134939.htm
Digestive Disease Week. "Adalimumab levels detected in cord blood and infants exposed in utero, researchers report." ScienceDaily. www.sciencedaily.com/releases/2011/05/110508134939.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins